Cargando…

Estradiol Replacement at the Critical Period Protects Hippocampal Neural Stem Cells to Improve Cognition in APP/PS1 Mice

It has been suggested that there is a critical window for estrogen replacement therapy (ERT) in postmenopausal women with Alzheimer’s disease (AD); however, supporting evidence is lacking. To address this issue, we investigated the effective period for estradiol (E2) treatment using a mouse model of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qin, Yaoyao, An, Dong, Xu, Weixing, Qi, Xiuting, Wang, Xiaoli, Chen, Ling, Chen, Lei, Sha, Sha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438824/ https://www.ncbi.nlm.nih.gov/pubmed/32903757 http://dx.doi.org/10.3389/fnagi.2020.00240

Ejemplares similares

ZIP9 mediates the effects of DHT on learning, memory and hippocampal synaptic plasticity of male Tfm and APP/PS1 mice
por: Song, Leigang, et al.
Publicado: (2023)

Active constituent of Polygala tenuifolia attenuates cognitive deficits by rescuing hippocampal neurogenesis in APP/PS1 transgenic mice
por: Wang, Xiao-feng, et al.
Publicado: (2021)

Effect of estradiol replacement on hippocampal concentrations of estrogens in aged rhesus macaques maintained on an obesogenic diet
por: Prokai, Laszlo, et al.
Publicado: (2023)

20(S)-protopanaxadiol and oleanolic acid ameliorate cognitive deficits in APP/PS1 transgenic mice by enhancing hippocampal neurogenesis
por: Lin, Kaili, et al.
Publicado: (2021)

DNA vaccines targeting amyloid-β oligomer ameliorate cognitive deficits of aged APP/PS1/tau triple-transgenic mouse models of Alzheimer’s disease
por: Sha, Sha, et al.
Publicado: (2022)

Treadmill Exercise Decreases Aβ Deposition and Counteracts Cognitive Decline in APP/PS1 Mice, Possibly via Hippocampal Microglia Modifications
por: Zhang, Xianliang, et al.
Publicado: (2019)

Repeated inhibition of sigma-1 receptor suppresses GABA(A) receptor expression and long-term depression in the nucleus accumbens leading to depressive-like behaviors
por: Qin, Yaoyao, et al.
Publicado: (2022)

Electroacupuncture Mitigates Hippocampal Cognitive Impairments by Reducing BACE1 Deposition and Activating PKA in APP/PS1 Double Transgenic Mice
por: Tang, Yinshan, et al.
Publicado: (2019)

Treadmill Exercise Ameliorates Adult Hippocampal Neurogenesis Possibly by Adjusting the APP Proteolytic Pathway in APP/PS1 Transgenic Mice
por: Yu, Haizhen, et al.
Publicado: (2021)

Roles of Testosterone and Estradiol in Mediation of Acute Neuroendocrine and Electroencephalographic Effects of Sevoflurane During the Sensitive Period in Rats
por: Li, Ningtao, et al.
Publicado: (2020)

Deficit in hippocampal ripples does not preclude spatial memory formation in APP/PS1 mice
por: Jura, Bartosz, et al.
Publicado: (2019)

Protective Effect of 17β-Estradiol Upon Hippocampal Spine Density and Cognitive Function in an Animal Model of Vascular Dementia
por: Zhu, Ying, et al.
Publicado: (2017)

Synaptic plasticity in hippocampal CA1 neurons and learning behavior in acute kidney injury, and estradiol replacement in ovariectomized rats
por: Sharifi, Fatemeh, et al.
Publicado: (2019)

Neonatal inflammation increases hippocampal KCC2 expression through methylation-mediated TGF-β1 downregulation leading to impaired hippocampal cognitive function and synaptic plasticity in adult mice
por: Rong, Jing, et al.
Publicado: (2023)

Fluoxetine Promotes Hippocampal Oligodendrocyte Maturation and Delays Learning and Memory Decline in APP/PS1 Mice
por: Chao, Feng-lei, et al.
Publicado: (2021)

Effects of triptolide on hippocampal microglial cells and astrocytes in the APP/PS1 double transgenic mouse model of Alzheimer's disease
por: Li, Jian-ming, et al.
Publicado: (2016)

A Neural Sensor with a Nanocomposite Interface for the Study of Spike Characteristics of Hippocampal Neurons under Learning Training
por: Xu, Shihong, et al.
Publicado: (2022)

Navβ2 knockdown improves cognition in APP/PS1 mice by partially inhibiting seizures and APP amyloid processing
por: Hu, Tao, et al.
Publicado: (2017)

(−)-Epigallocatechin-3-Gallate Ameliorates Learning and Memory Deficits by Adjusting the Balance of TrkA/p75(NTR) Signaling in APP/PS1 Transgenic Mice
por: Liu, Mingyan, et al.
Publicado: (2013)

The effect of hyperthyroidism on cognitive function, neuroinflammation, and necroptosis in APP/PS1 mice
por: Lou, Kai, et al.
Publicado: (2023)

Lithium Improves Hippocampal Neurogenesis, Neuropathology and Cognitive Functions in APP Mutant Mice
por: Fiorentini, Anna, et al.
Publicado: (2010)

Jujuboside A prevents sleep loss-induced disturbance of hippocampal neuronal excitability and memory impairment in young APP/PS1 mice
por: Tabassum, Sidra, et al.
Publicado: (2019)

Effects of Curculigoside on Memory Impairment and Bone Loss via Anti-Oxidative Character in APP/PS1 Mutated Transgenic Mice
por: Zhao, Lu, et al.
Publicado: (2015)

Isoniazid improves cognitive performance, clears Aβ plaques, and protects dendritic synapses in APP/PS1 transgenic mice
por: Chen, Jiacheng, et al.
Publicado: (2023)

Infantile amnesia reflects a developmental critical period for hippocampal learning
por: Travaglia, Alessio, et al.
Publicado: (2016)

Preventing Postpartum Depression in the Early Postpartum Period Using an App-Based Cognitive Behavioral Therapy Program: A Pilot Randomized Controlled Study
por: Qin, Xiaoli, et al.
Publicado: (2022)

PS magnet replaced
Publicado: (1970)

The Environmental Estrogen Bisphenol A Inhibits Estradiol-Induced Hippocampal Synaptogenesis
por: MacLusky, Neil J., et al.
Publicado: (2005)

Vitis vinifera L. Flavones Regulate Hippocampal Neurons via Autophagy in APP/PS1 Alzheimer Model Mice
por: Zhang, Peng, et al.
Publicado: (2022)

Exercise-Induced Cognitive Improvement Is Associated with Sodium Channel-Mediated Excitability in APP/PS1 Mice
por: Tan, Ya-Xin, et al.
Publicado: (2020)

Pan-PPAR Modulation Effectively Protects APP/PS1 Mice from Amyloid Deposition and Cognitive Deficits
por: Kummer, Markus P., et al.
Publicado: (2014)

Population Pharmacokinetics and Dosing Optimization of Gentamicin in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy
por: He, Sha, et al.
Publicado: (2022)

Rescue of cognitive deficits in APP/PS1 mice by accelerating the aggregation of β-amyloid peptide
por: Zhang, Jian-Xiang, et al.
Publicado: (2019)

Electroacupuncture decreases cognitive impairment and promotes neurogenesis in the APP/PS1 transgenic mice
por: Li, Xuying, et al.
Publicado: (2014)

Naringin Dihydrochalcone Ameliorates Cognitive Deficits and Neuropathology in APP/PS1 Transgenic Mice
por: Yang, Wenjuan, et al.
Publicado: (2018)

De Novo Synthesized Estradiol Protects against Methylmercury-Induced Neurotoxicity in Cultured Rat Hippocampal Slices
por: Yamazaki, Takeshi, et al.
Publicado: (2013)

Active compounds of herbs ameliorate impaired cognition in APP/PS1 mouse model of Alzheimer’s disease
por: Yu, WenJun, et al.
Publicado: (2019)

A critical period for learning and plastic changes at hippocampal CA1 synapses
por: Sakimoto, Yuya, et al.
Publicado: (2022)

PS166. Relationship of Hippocampal asymmetry and cognitive function in first-episode drug naïve major depressive disorder
por: Chen, Ching-Wen, et al.
Publicado: (2016)

Enhanced Medial Prefrontal Cortex and Hippocampal Activity Improves Memory Generalization in APP/PS1 Mice: A Multimodal Animal MRI Study
por: Liu, Weilin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_8ekuatl0ipqe2oajeaf151kf90