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Alteration of Brain Gray Matter Density After 24 h of Sleep Deprivation in Healthy Adults
It has been reported that one night of acute sleep deprivation (SD) could induce brain structural changes at the synaptic and neuronal levels in animal studies, and could lead to white matter microstructure and cortical thickness change in human neuroimaging studies. In this study, we focused on cha...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438917/ https://www.ncbi.nlm.nih.gov/pubmed/32903801 http://dx.doi.org/10.3389/fnins.2020.00754 |
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author | Sun, Jinbo Zhao, Rui Yang, Xuejuan Deng, Hui Zhu, Yuanqiang Chen, Yao Yuan, Kai Xi, Yibin Yin, Hong Qin, Wei |
author_facet | Sun, Jinbo Zhao, Rui Yang, Xuejuan Deng, Hui Zhu, Yuanqiang Chen, Yao Yuan, Kai Xi, Yibin Yin, Hong Qin, Wei |
author_sort | Sun, Jinbo |
collection | PubMed |
description | It has been reported that one night of acute sleep deprivation (SD) could induce brain structural changes at the synaptic and neuronal levels in animal studies, and could lead to white matter microstructure and cortical thickness change in human neuroimaging studies. In this study, we focused on changes of brain gray matter density (GMD) after one night of acute SD, which has not been explored previously. Twenty-three normal young participants completed the experiment. Each participant underwent twice T1-weighted structural image scanning with one at 08:00 after normal sleep [resting wakeful (RW)] and the other at 08:00 after 24 h of SD. Using voxel-based morphometry (VBM) analysis by FSL-VBM software, we compared GMD between RW and SD. In addition, the gray matter volume (GMV) and cortical thickness (CT) were also calculated based on volumetric and surface measures with FreeSurfer software. The psychomotor vigilance test (PVT) and the Karolinska Sleepiness Scale (KSS) were performed and evaluated for correlation analysis with GMD, GMV, and CT of the significant regions. Our results showed that the GMD in the right frontal pole (FP), right superior frontal gyrus (SFG), and right middle frontal gyrus significantly increased and GMV and CT in the right temporal pole (TP) significantly decreased after 24 h of acute SD. SD-induced changes in GMD in the right middle frontal gyrus were positively correlated with the changes of KSS scores (Spearman’s correlation r = 0.625, p = 0.0014, Bonferroni correction with p < 0.05/25). Taken together, our findings suggested that one night of acute SD could induce substantial brain structure changes and the alterations in GMD in the right middle frontal gyrus (MFG) might be implicated in sleepiness after SD. |
format | Online Article Text |
id | pubmed-7438917 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74389172020-09-03 Alteration of Brain Gray Matter Density After 24 h of Sleep Deprivation in Healthy Adults Sun, Jinbo Zhao, Rui Yang, Xuejuan Deng, Hui Zhu, Yuanqiang Chen, Yao Yuan, Kai Xi, Yibin Yin, Hong Qin, Wei Front Neurosci Neuroscience It has been reported that one night of acute sleep deprivation (SD) could induce brain structural changes at the synaptic and neuronal levels in animal studies, and could lead to white matter microstructure and cortical thickness change in human neuroimaging studies. In this study, we focused on changes of brain gray matter density (GMD) after one night of acute SD, which has not been explored previously. Twenty-three normal young participants completed the experiment. Each participant underwent twice T1-weighted structural image scanning with one at 08:00 after normal sleep [resting wakeful (RW)] and the other at 08:00 after 24 h of SD. Using voxel-based morphometry (VBM) analysis by FSL-VBM software, we compared GMD between RW and SD. In addition, the gray matter volume (GMV) and cortical thickness (CT) were also calculated based on volumetric and surface measures with FreeSurfer software. The psychomotor vigilance test (PVT) and the Karolinska Sleepiness Scale (KSS) were performed and evaluated for correlation analysis with GMD, GMV, and CT of the significant regions. Our results showed that the GMD in the right frontal pole (FP), right superior frontal gyrus (SFG), and right middle frontal gyrus significantly increased and GMV and CT in the right temporal pole (TP) significantly decreased after 24 h of acute SD. SD-induced changes in GMD in the right middle frontal gyrus were positively correlated with the changes of KSS scores (Spearman’s correlation r = 0.625, p = 0.0014, Bonferroni correction with p < 0.05/25). Taken together, our findings suggested that one night of acute SD could induce substantial brain structure changes and the alterations in GMD in the right middle frontal gyrus (MFG) might be implicated in sleepiness after SD. Frontiers Media S.A. 2020-08-11 /pmc/articles/PMC7438917/ /pubmed/32903801 http://dx.doi.org/10.3389/fnins.2020.00754 Text en Copyright © 2020 Sun, Zhao, Yang, Deng, Zhu, Chen, Yuan, Xi, Yin and Qin. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Sun, Jinbo Zhao, Rui Yang, Xuejuan Deng, Hui Zhu, Yuanqiang Chen, Yao Yuan, Kai Xi, Yibin Yin, Hong Qin, Wei Alteration of Brain Gray Matter Density After 24 h of Sleep Deprivation in Healthy Adults |
title | Alteration of Brain Gray Matter Density After 24 h of Sleep Deprivation in Healthy Adults |
title_full | Alteration of Brain Gray Matter Density After 24 h of Sleep Deprivation in Healthy Adults |
title_fullStr | Alteration of Brain Gray Matter Density After 24 h of Sleep Deprivation in Healthy Adults |
title_full_unstemmed | Alteration of Brain Gray Matter Density After 24 h of Sleep Deprivation in Healthy Adults |
title_short | Alteration of Brain Gray Matter Density After 24 h of Sleep Deprivation in Healthy Adults |
title_sort | alteration of brain gray matter density after 24 h of sleep deprivation in healthy adults |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438917/ https://www.ncbi.nlm.nih.gov/pubmed/32903801 http://dx.doi.org/10.3389/fnins.2020.00754 |
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