A Review of Clinical Applications and Side Effects of Methotrexate in Ophthalmology

Methotrexate (MTX) is a folate analog widely used against a range of diseases including malignancies and autoimmune disorders. Its high effectiveness-price ratio also won extensive application in ophthalmology. On the other hand, although MTX has an excellent pharmacological efficacy, MTX associated...

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Detalles Bibliográficos
Autores principales: Wang, Ge, Peng, Xiaoyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439192/
https://www.ncbi.nlm.nih.gov/pubmed/32850138
http://dx.doi.org/10.1155/2020/1537689
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author Wang, Ge
Peng, Xiaoyan
author_facet Wang, Ge
Peng, Xiaoyan
author_sort Wang, Ge
collection PubMed
description Methotrexate (MTX) is a folate analog widely used against a range of diseases including malignancies and autoimmune disorders. Its high effectiveness-price ratio also won extensive application in ophthalmology. On the other hand, although MTX has an excellent pharmacological efficacy, MTX associated side effects in clinical use, which vary from patient to patient, are nonnegligible. There is no comparatively systematic review on MTX associated side effects and its risk factors. This review aimed to reveal novel clinical approaches of MTX and its adverse effects in order to provide a reference for ophthalmic scholars in clinical application of MTX.
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spelling pubmed-74391922020-08-25 A Review of Clinical Applications and Side Effects of Methotrexate in Ophthalmology Wang, Ge Peng, Xiaoyan J Ophthalmol Review Article Methotrexate (MTX) is a folate analog widely used against a range of diseases including malignancies and autoimmune disorders. Its high effectiveness-price ratio also won extensive application in ophthalmology. On the other hand, although MTX has an excellent pharmacological efficacy, MTX associated side effects in clinical use, which vary from patient to patient, are nonnegligible. There is no comparatively systematic review on MTX associated side effects and its risk factors. This review aimed to reveal novel clinical approaches of MTX and its adverse effects in order to provide a reference for ophthalmic scholars in clinical application of MTX. Hindawi 2020-08-11 /pmc/articles/PMC7439192/ /pubmed/32850138 http://dx.doi.org/10.1155/2020/1537689 Text en Copyright © 2020 Ge Wang and Xiaoyan Peng. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wang, Ge
Peng, Xiaoyan
A Review of Clinical Applications and Side Effects of Methotrexate in Ophthalmology
title A Review of Clinical Applications and Side Effects of Methotrexate in Ophthalmology
title_full A Review of Clinical Applications and Side Effects of Methotrexate in Ophthalmology
title_fullStr A Review of Clinical Applications and Side Effects of Methotrexate in Ophthalmology
title_full_unstemmed A Review of Clinical Applications and Side Effects of Methotrexate in Ophthalmology
title_short A Review of Clinical Applications and Side Effects of Methotrexate in Ophthalmology
title_sort review of clinical applications and side effects of methotrexate in ophthalmology
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439192/
https://www.ncbi.nlm.nih.gov/pubmed/32850138
http://dx.doi.org/10.1155/2020/1537689
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