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Unraveling the Dynamics of Antibody-Antigen Interaction by DNA Origami
To investigate the dynamic interaction between antibody and antigen, Fan et al. rationally designed a triangular DNA origami framework to spatially organize the antigenic epitopes at the nanoscale and thus to monitor the transient binding kinetics of the dynamic antigen-antibody complexes at room te...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Jilin University and The Editorial Department of Chemical Research in Chinese Universities
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439236/ https://www.ncbi.nlm.nih.gov/pubmed/32839648 http://dx.doi.org/10.1007/s40242-020-0252-6 |
Sumario: | To investigate the dynamic interaction between antibody and antigen, Fan et al. rationally designed a triangular DNA origami framework to spatially organize the antigenic epitopes at the nanoscale and thus to monitor the transient binding kinetics of the dynamic antigen-antibody complexes at room temperature. This study provides a straightforward, designable and programmable strategy to investigate the transition kinetics of antibody-antigen interaction at a single-molecule level and improve the understanding toward the design of the next-generation antibodies and vaccines for various biomedical applications. This work has been published online in Nature Communications on June 19, 2020. |
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