Cargando…

Bi-stability of SUDR+K model of epidemics and test kits applied to COVID-19

Motivated by the many diverse responses of different countries to the COVID-19 emergency, here we develop a toy model of the dependence of the epidemics spreading on the availability of tests for disease. Our model, that we call SUDR+K, grounds on the usual SIR model, with the difference of splittin...

Descripción completa

Detalles Bibliográficos
Autores principales: Zlatić, Vinko, Barjašić, Irena, Kadović, Andrea, Štefančić, Hrvoje, Gabrielli, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439243/
https://www.ncbi.nlm.nih.gov/pubmed/32839639
http://dx.doi.org/10.1007/s11071-020-05888-w
_version_ 1783572940911017984
author Zlatić, Vinko
Barjašić, Irena
Kadović, Andrea
Štefančić, Hrvoje
Gabrielli, Andrea
author_facet Zlatić, Vinko
Barjašić, Irena
Kadović, Andrea
Štefančić, Hrvoje
Gabrielli, Andrea
author_sort Zlatić, Vinko
collection PubMed
description Motivated by the many diverse responses of different countries to the COVID-19 emergency, here we develop a toy model of the dependence of the epidemics spreading on the availability of tests for disease. Our model, that we call SUDR+K, grounds on the usual SIR model, with the difference of splitting the total fraction of infected individuals in two components: patients that are still undetected and patients that have been already detected through tests. Moreover, we assume that available tests increase at a constant rate from the beginning of epidemics but are consumed to detect infected individuals. Strikingly, we find a bi-stable behavior between a phase with a giant fraction of infected and a phase with a very small fraction. We show that the separation between these two regimes is governed by a match between the rate of testing and a rate of infection spread at given time. We also show that the existence of two phases does not depend on the mathematical choice of the form of the term describing the rate at which undetected individuals are tested and detected. Presented research implies that a vigorous early testing activity, before the epidemics enters its giant phase, can potentially keep epidemics under control, and that even a very small change of the testing rate around the bi-stable point can determine a fluctuation of the size of the whole epidemics of various orders of magnitude. For the real application of realistic model to ongoing epidemics, we would gladly collaborate with field epidemiologists in order to develop quantitative models of testing process.
format Online
Article
Text
id pubmed-7439243
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Springer Netherlands
record_format MEDLINE/PubMed
spelling pubmed-74392432020-08-20 Bi-stability of SUDR+K model of epidemics and test kits applied to COVID-19 Zlatić, Vinko Barjašić, Irena Kadović, Andrea Štefančić, Hrvoje Gabrielli, Andrea Nonlinear Dyn Original Paper Motivated by the many diverse responses of different countries to the COVID-19 emergency, here we develop a toy model of the dependence of the epidemics spreading on the availability of tests for disease. Our model, that we call SUDR+K, grounds on the usual SIR model, with the difference of splitting the total fraction of infected individuals in two components: patients that are still undetected and patients that have been already detected through tests. Moreover, we assume that available tests increase at a constant rate from the beginning of epidemics but are consumed to detect infected individuals. Strikingly, we find a bi-stable behavior between a phase with a giant fraction of infected and a phase with a very small fraction. We show that the separation between these two regimes is governed by a match between the rate of testing and a rate of infection spread at given time. We also show that the existence of two phases does not depend on the mathematical choice of the form of the term describing the rate at which undetected individuals are tested and detected. Presented research implies that a vigorous early testing activity, before the epidemics enters its giant phase, can potentially keep epidemics under control, and that even a very small change of the testing rate around the bi-stable point can determine a fluctuation of the size of the whole epidemics of various orders of magnitude. For the real application of realistic model to ongoing epidemics, we would gladly collaborate with field epidemiologists in order to develop quantitative models of testing process. Springer Netherlands 2020-08-20 2020 /pmc/articles/PMC7439243/ /pubmed/32839639 http://dx.doi.org/10.1007/s11071-020-05888-w Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Paper
Zlatić, Vinko
Barjašić, Irena
Kadović, Andrea
Štefančić, Hrvoje
Gabrielli, Andrea
Bi-stability of SUDR+K model of epidemics and test kits applied to COVID-19
title Bi-stability of SUDR+K model of epidemics and test kits applied to COVID-19
title_full Bi-stability of SUDR+K model of epidemics and test kits applied to COVID-19
title_fullStr Bi-stability of SUDR+K model of epidemics and test kits applied to COVID-19
title_full_unstemmed Bi-stability of SUDR+K model of epidemics and test kits applied to COVID-19
title_short Bi-stability of SUDR+K model of epidemics and test kits applied to COVID-19
title_sort bi-stability of sudr+k model of epidemics and test kits applied to covid-19
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439243/
https://www.ncbi.nlm.nih.gov/pubmed/32839639
http://dx.doi.org/10.1007/s11071-020-05888-w
work_keys_str_mv AT zlaticvinko bistabilityofsudrkmodelofepidemicsandtestkitsappliedtocovid19
AT barjasicirena bistabilityofsudrkmodelofepidemicsandtestkitsappliedtocovid19
AT kadovicandrea bistabilityofsudrkmodelofepidemicsandtestkitsappliedtocovid19
AT stefancichrvoje bistabilityofsudrkmodelofepidemicsandtestkitsappliedtocovid19
AT gabrielliandrea bistabilityofsudrkmodelofepidemicsandtestkitsappliedtocovid19