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Burden of respiratory syncytial virus hospitalisation among infants born at 32–35 weeks' gestational age in the Northern Hemisphere: pooled analysis of seven studies

To provide comprehensive information on the epidemiology and burden of respiratory syncytial virus hospitalisation (RSVH) in preterm infants, a pooled analysis was undertaken of seven multicentre, prospective, observational studies from across the Northern Hemisphere (2000–2014). Data from all 32(0)...

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Autores principales: Lanari, M., Anderson, E.J., Sheridan-Pereira, M., Carbonell-Estrany, X., Paes, B., Rodgers-Gray, B.S., Fullarton, J. R., Grubb, E., Blanken, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439292/
https://www.ncbi.nlm.nih.gov/pubmed/32799945
http://dx.doi.org/10.1017/S0950268820001661
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author Lanari, M.
Anderson, E.J.
Sheridan-Pereira, M.
Carbonell-Estrany, X.
Paes, B.
Rodgers-Gray, B.S.
Fullarton, J. R.
Grubb, E.
Blanken, M.
author_facet Lanari, M.
Anderson, E.J.
Sheridan-Pereira, M.
Carbonell-Estrany, X.
Paes, B.
Rodgers-Gray, B.S.
Fullarton, J. R.
Grubb, E.
Blanken, M.
author_sort Lanari, M.
collection PubMed
description To provide comprehensive information on the epidemiology and burden of respiratory syncytial virus hospitalisation (RSVH) in preterm infants, a pooled analysis was undertaken of seven multicentre, prospective, observational studies from across the Northern Hemisphere (2000–2014). Data from all 32(0)–35(6) weeks' gestational age (wGA) infants without comorbidity were analysed. RSVH occurred in 534/14 504 (3.7%) infants; equating to a rate of 5.65 per 100 patient-seasons, with the rate in individual wGA groups dependent upon exposure time (P = 0.032). Most RSVHs (60.1%) occurred in December–January. Median age at RSVH was 88 days (interquartile range (IQR): 54–159). Respiratory support was required by 82.0% of infants: oxygen in 70.4% (median 4 (IQR: 2–6) days); non-invasive ventilation in 19.3% (median 3 (IQR: 2–5) days); and mechanical ventilation in 10.2% (median 5 (IQR: 3–7) days). Intensive care unit admission was required by 17.9% of infants (median 6 days (IQR: 2–8) days). Median overall hospital length of stay (LOS) was 5 (IQR: 3–8) days. Hospital resource use was similar across wGA groups except for overall LOS, which was shortest in those born 35 wGA (median 3 vs. 4–6 days for 32–34 wGA; P < 0.001). Strategies to reduce the burden of RSVH in otherwise healthy 32–35 wGA infants are indicated.
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spelling pubmed-74392922020-09-02 Burden of respiratory syncytial virus hospitalisation among infants born at 32–35 weeks' gestational age in the Northern Hemisphere: pooled analysis of seven studies Lanari, M. Anderson, E.J. Sheridan-Pereira, M. Carbonell-Estrany, X. Paes, B. Rodgers-Gray, B.S. Fullarton, J. R. Grubb, E. Blanken, M. Epidemiol Infect Original Paper To provide comprehensive information on the epidemiology and burden of respiratory syncytial virus hospitalisation (RSVH) in preterm infants, a pooled analysis was undertaken of seven multicentre, prospective, observational studies from across the Northern Hemisphere (2000–2014). Data from all 32(0)–35(6) weeks' gestational age (wGA) infants without comorbidity were analysed. RSVH occurred in 534/14 504 (3.7%) infants; equating to a rate of 5.65 per 100 patient-seasons, with the rate in individual wGA groups dependent upon exposure time (P = 0.032). Most RSVHs (60.1%) occurred in December–January. Median age at RSVH was 88 days (interquartile range (IQR): 54–159). Respiratory support was required by 82.0% of infants: oxygen in 70.4% (median 4 (IQR: 2–6) days); non-invasive ventilation in 19.3% (median 3 (IQR: 2–5) days); and mechanical ventilation in 10.2% (median 5 (IQR: 3–7) days). Intensive care unit admission was required by 17.9% of infants (median 6 days (IQR: 2–8) days). Median overall hospital length of stay (LOS) was 5 (IQR: 3–8) days. Hospital resource use was similar across wGA groups except for overall LOS, which was shortest in those born 35 wGA (median 3 vs. 4–6 days for 32–34 wGA; P < 0.001). Strategies to reduce the burden of RSVH in otherwise healthy 32–35 wGA infants are indicated. Cambridge University Press 2020-08-17 /pmc/articles/PMC7439292/ /pubmed/32799945 http://dx.doi.org/10.1017/S0950268820001661 Text en © The Author(s) 2020 http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Paper
Lanari, M.
Anderson, E.J.
Sheridan-Pereira, M.
Carbonell-Estrany, X.
Paes, B.
Rodgers-Gray, B.S.
Fullarton, J. R.
Grubb, E.
Blanken, M.
Burden of respiratory syncytial virus hospitalisation among infants born at 32–35 weeks' gestational age in the Northern Hemisphere: pooled analysis of seven studies
title Burden of respiratory syncytial virus hospitalisation among infants born at 32–35 weeks' gestational age in the Northern Hemisphere: pooled analysis of seven studies
title_full Burden of respiratory syncytial virus hospitalisation among infants born at 32–35 weeks' gestational age in the Northern Hemisphere: pooled analysis of seven studies
title_fullStr Burden of respiratory syncytial virus hospitalisation among infants born at 32–35 weeks' gestational age in the Northern Hemisphere: pooled analysis of seven studies
title_full_unstemmed Burden of respiratory syncytial virus hospitalisation among infants born at 32–35 weeks' gestational age in the Northern Hemisphere: pooled analysis of seven studies
title_short Burden of respiratory syncytial virus hospitalisation among infants born at 32–35 weeks' gestational age in the Northern Hemisphere: pooled analysis of seven studies
title_sort burden of respiratory syncytial virus hospitalisation among infants born at 32–35 weeks' gestational age in the northern hemisphere: pooled analysis of seven studies
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439292/
https://www.ncbi.nlm.nih.gov/pubmed/32799945
http://dx.doi.org/10.1017/S0950268820001661
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