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Epidemiological study of Trichosporon asahii infections over the past 23 years
Trichosporon is a yeast-like basidiomycete, a conditional pathogenic fungus that is rare in the clinic but often causes fatal infections in immunocompromised individuals. Trichosporon asahii is the most common pathogenic fungus in this genus and the occurrence of infections has dramatically increase...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439294/ https://www.ncbi.nlm.nih.gov/pubmed/32703332 http://dx.doi.org/10.1017/S0950268820001624 |
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author | Li, Haitao Guo, Meihong Wang, Congmin Li, Yibo Fernandez, Anne Marie Ferraro, Thomas N. Yang, Rongya Chen, Yong |
author_facet | Li, Haitao Guo, Meihong Wang, Congmin Li, Yibo Fernandez, Anne Marie Ferraro, Thomas N. Yang, Rongya Chen, Yong |
author_sort | Li, Haitao |
collection | PubMed |
description | Trichosporon is a yeast-like basidiomycete, a conditional pathogenic fungus that is rare in the clinic but often causes fatal infections in immunocompromised individuals. Trichosporon asahii is the most common pathogenic fungus in this genus and the occurrence of infections has dramatically increased in recent years. Here, we report a systematic literature review detailing 140 cases of T. asahii infection reported during the past 23 years. Statistical analysis shows that T. asahii infections were most frequently reported within immunodeficient or immunocompromised patients commonly with blood diseases. Antibiotic use, invasive medical equipment and chemotherapy were the leading risk factors for acquiring infection. In vitro susceptibility, clinical information and prognosis analysis showed that voriconazole is the primary drug of choice in the treatment of T. asahii infection. Combination treatment with voriconazole and amphotericin B did not show superiority over either drug alone. Finally, we found that the types of infections prevalent in China are significantly different from those in other countries. These results provide detailed information and relevant clinical treatment strategies for the diagnosis and treatment of T. asahii infection. |
format | Online Article Text |
id | pubmed-7439294 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-74392942020-09-02 Epidemiological study of Trichosporon asahii infections over the past 23 years Li, Haitao Guo, Meihong Wang, Congmin Li, Yibo Fernandez, Anne Marie Ferraro, Thomas N. Yang, Rongya Chen, Yong Epidemiol Infect Review Trichosporon is a yeast-like basidiomycete, a conditional pathogenic fungus that is rare in the clinic but often causes fatal infections in immunocompromised individuals. Trichosporon asahii is the most common pathogenic fungus in this genus and the occurrence of infections has dramatically increased in recent years. Here, we report a systematic literature review detailing 140 cases of T. asahii infection reported during the past 23 years. Statistical analysis shows that T. asahii infections were most frequently reported within immunodeficient or immunocompromised patients commonly with blood diseases. Antibiotic use, invasive medical equipment and chemotherapy were the leading risk factors for acquiring infection. In vitro susceptibility, clinical information and prognosis analysis showed that voriconazole is the primary drug of choice in the treatment of T. asahii infection. Combination treatment with voriconazole and amphotericin B did not show superiority over either drug alone. Finally, we found that the types of infections prevalent in China are significantly different from those in other countries. These results provide detailed information and relevant clinical treatment strategies for the diagnosis and treatment of T. asahii infection. Cambridge University Press 2020-07-24 /pmc/articles/PMC7439294/ /pubmed/32703332 http://dx.doi.org/10.1017/S0950268820001624 Text en © The Author(s) 2020 http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Li, Haitao Guo, Meihong Wang, Congmin Li, Yibo Fernandez, Anne Marie Ferraro, Thomas N. Yang, Rongya Chen, Yong Epidemiological study of Trichosporon asahii infections over the past 23 years |
title | Epidemiological study of Trichosporon asahii infections over the past 23 years |
title_full | Epidemiological study of Trichosporon asahii infections over the past 23 years |
title_fullStr | Epidemiological study of Trichosporon asahii infections over the past 23 years |
title_full_unstemmed | Epidemiological study of Trichosporon asahii infections over the past 23 years |
title_short | Epidemiological study of Trichosporon asahii infections over the past 23 years |
title_sort | epidemiological study of trichosporon asahii infections over the past 23 years |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439294/ https://www.ncbi.nlm.nih.gov/pubmed/32703332 http://dx.doi.org/10.1017/S0950268820001624 |
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