Diverse noncoding mutations contribute to deregulation of cis-regulatory landscape in pediatric cancers

Interpreting the function of noncoding mutations in cancer genomes remains a major challenge. Here, we developed a computational framework to identify putative causal noncoding mutations of all classes by joint analysis of mutation and gene expression data. We identified thousands of SNVs/small inde...

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Detalles Bibliográficos
Autores principales: He, Bing, Gao, Peng, Ding, Yang-Yang, Chen, Chia-Hui, Chen, Gregory, Chen, Changya, Kim, Hannah, Tasian, Sarah K., Hunger, Stephen P., Tan, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439310/
https://www.ncbi.nlm.nih.gov/pubmed/32832663
http://dx.doi.org/10.1126/sciadv.aba3064

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