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Serum miR‐195‐5p is upregulated in gestational diabetes mellitus

BACKGROUND: Gestational diabetes mellitus (GDM) is defined as varying degrees of glucose intolerance with an onset or first recognition during pregnancy in women without previously diagnosed diabetes. Accumulating evidence indicates that miRNAs exert crucial roles in the pathogenesis and development...

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Autores principales: Wang, Jianping, Pan, Yuanyuan, Dai, Fen, Wang, Fan, Qiu, Haifan, Huang, Xianping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439337/
https://www.ncbi.nlm.nih.gov/pubmed/32301163
http://dx.doi.org/10.1002/jcla.23325
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author Wang, Jianping
Pan, Yuanyuan
Dai, Fen
Wang, Fan
Qiu, Haifan
Huang, Xianping
author_facet Wang, Jianping
Pan, Yuanyuan
Dai, Fen
Wang, Fan
Qiu, Haifan
Huang, Xianping
author_sort Wang, Jianping
collection PubMed
description BACKGROUND: Gestational diabetes mellitus (GDM) is defined as varying degrees of glucose intolerance with an onset or first recognition during pregnancy in women without previously diagnosed diabetes. Accumulating evidence indicates that miRNAs exert crucial roles in the pathogenesis and development of diabetes, including GDM. In the present study, we aimed to determine the clinical performance of miR‐195‐5p in GDM. METHODS: First, the miR‐195‐5p expressions in serum samples from healthy pregnant women and women with GDM at 25 weeks pregnancy were detected using real‐time polymerase chain reaction (RT‐qPCR). Then, receive characteristic (ROC) curve was used to determine the diagnostic value of miR‐195‐5p in GDM. Finally, the correlation analysis of miR‐195‐5p expression with related clinicopathological factors was carried out to determine the clinical value of miR‐195‐5p in GDM. RESULTS: In this study, we found that miR‐195‐5p expression was significantly increased in serum samples from GDM patients as compared with that in healthy pregnancies. Furthermore, miR‐195‐5p might be a putative biomarker for GDM diagnosis with an area under the curve (AUC) of 0.8451; the cutoff value was 1.598, sensitivity was 73.69%, specificity was 96.85%, accuracy was 81.26%, and Youden index was 70.54%. Expression of miR‐195‐5p was positively associated with fasting plasma glucose, one‐hour plasma glucose, and two‐hour plasma glucose. CONCLUSION: miR‐195‐5p might function as a putative diagnostic biomarker for GDM and contribute to identifying at‐risk mothers in pregnancy.
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spelling pubmed-74393372020-08-21 Serum miR‐195‐5p is upregulated in gestational diabetes mellitus Wang, Jianping Pan, Yuanyuan Dai, Fen Wang, Fan Qiu, Haifan Huang, Xianping J Clin Lab Anal Research Articles BACKGROUND: Gestational diabetes mellitus (GDM) is defined as varying degrees of glucose intolerance with an onset or first recognition during pregnancy in women without previously diagnosed diabetes. Accumulating evidence indicates that miRNAs exert crucial roles in the pathogenesis and development of diabetes, including GDM. In the present study, we aimed to determine the clinical performance of miR‐195‐5p in GDM. METHODS: First, the miR‐195‐5p expressions in serum samples from healthy pregnant women and women with GDM at 25 weeks pregnancy were detected using real‐time polymerase chain reaction (RT‐qPCR). Then, receive characteristic (ROC) curve was used to determine the diagnostic value of miR‐195‐5p in GDM. Finally, the correlation analysis of miR‐195‐5p expression with related clinicopathological factors was carried out to determine the clinical value of miR‐195‐5p in GDM. RESULTS: In this study, we found that miR‐195‐5p expression was significantly increased in serum samples from GDM patients as compared with that in healthy pregnancies. Furthermore, miR‐195‐5p might be a putative biomarker for GDM diagnosis with an area under the curve (AUC) of 0.8451; the cutoff value was 1.598, sensitivity was 73.69%, specificity was 96.85%, accuracy was 81.26%, and Youden index was 70.54%. Expression of miR‐195‐5p was positively associated with fasting plasma glucose, one‐hour plasma glucose, and two‐hour plasma glucose. CONCLUSION: miR‐195‐5p might function as a putative diagnostic biomarker for GDM and contribute to identifying at‐risk mothers in pregnancy. John Wiley and Sons Inc. 2020-04-17 /pmc/articles/PMC7439337/ /pubmed/32301163 http://dx.doi.org/10.1002/jcla.23325 Text en © 2020 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Wang, Jianping
Pan, Yuanyuan
Dai, Fen
Wang, Fan
Qiu, Haifan
Huang, Xianping
Serum miR‐195‐5p is upregulated in gestational diabetes mellitus
title Serum miR‐195‐5p is upregulated in gestational diabetes mellitus
title_full Serum miR‐195‐5p is upregulated in gestational diabetes mellitus
title_fullStr Serum miR‐195‐5p is upregulated in gestational diabetes mellitus
title_full_unstemmed Serum miR‐195‐5p is upregulated in gestational diabetes mellitus
title_short Serum miR‐195‐5p is upregulated in gestational diabetes mellitus
title_sort serum mir‐195‐5p is upregulated in gestational diabetes mellitus
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439337/
https://www.ncbi.nlm.nih.gov/pubmed/32301163
http://dx.doi.org/10.1002/jcla.23325
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