SirT7 auto-ADP-ribosylation regulates glucose starvation response through mH2A1

Sirtuins are key players of metabolic stress response. Originally described as deacetylases, some sirtuins also exhibit poorly understood mono–adenosine 5′-diphosphate (ADP)–ribosyltransferase (mADPRT) activity. We report that the deacetylase SirT7 is a dual sirtuin, as it also features auto-mADPRT...

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Detalles Bibliográficos
Autores principales: Simonet, Nicolás G., Thackray, Joshua K., Vazquez, Berta N., Ianni, Alessandro, Espinosa-Alcantud, Maria, Morales-Sanfrutos, Julia, Hurtado-Bagès, Sarah, Sabidó, Eduard, Buschbeck, Marcus, Tischfield, Jay, De La Torre, Carolina, Esteller, Manel, Braun, Thomas, Olivella, Mireia, Serrano, Lourdes, Vaquero, Alejandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439345/
https://www.ncbi.nlm.nih.gov/pubmed/32832656
http://dx.doi.org/10.1126/sciadv.aaz2590

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