Single C-to-T substitution using engineered APOBEC3G-nCas9 base editors with minimum genome- and transcriptome-wide off-target effects

Cytosine base editors (CBEs) enable efficient cytidine-to-thymidine (C-to-T) substitutions at targeted loci without double-stranded breaks. However, current CBEs edit all Cs within their activity windows, generating undesired bystander mutations. In the most challenging circumstance, when a bystande...

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Detalles Bibliográficos
Autores principales: Lee, Sangsin, Ding, Ning, Sun, Yidi, Yuan, Tanglong, Li, Jing, Yuan, Qichen, Liu, Lizhong, Yang, Jie, Wang, Qian, Kolomeisky, Anatoly B., Hilton, Isaac B., Zuo, Erwei, Gao, Xue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439359/
https://www.ncbi.nlm.nih.gov/pubmed/32832622
http://dx.doi.org/10.1126/sciadv.aba1773

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