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A potential disease monitoring and prognostic biomarker in cervical cancer patients: The clinical application of circular RNA_0018289
OBJECTIVE: This study aimed to investigate the tumor circular RNA_0018289 (circ_0018289) expression and its correlation with clinical characteristics as well as survival profiles in cervical cancer patients. METHODS: A hundred and ninety‐two cervical cancer patients who received surgical resection w...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439420/ https://www.ncbi.nlm.nih.gov/pubmed/32320103 http://dx.doi.org/10.1002/jcla.23340 |
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author | He, Jing Lv, Xin Zeng, Zhen |
author_facet | He, Jing Lv, Xin Zeng, Zhen |
author_sort | He, Jing |
collection | PubMed |
description | OBJECTIVE: This study aimed to investigate the tumor circular RNA_0018289 (circ_0018289) expression and its correlation with clinical characteristics as well as survival profiles in cervical cancer patients. METHODS: A hundred and ninety‐two cervical cancer patients who received surgical resection were recruited in this prospective study. Tumor tissue and paired adjacent tissue were obtained during the surgery, in which circ_0018289 expression was detected by reverse transcription quantitative polymerase chain reaction. Disease‐free survival (DFS) and overall survival (OS) were recorded. RESULTS: Circ_0018289 expression was upregulated in tumor tissue compared with paired adjacent tissue (P < .001), and receiver operative characteristic curve disclosed its good value for separating tumor tissue from adjacent tissue with an area under curve of 0.907 (95% CI: 0.879‐0.935). Additionally, tumor circ_0018289 expression was positively associated with tumor size (P = .009), lymph node metastasis (P = .005) and Federation International of Gynecology and Obstetrics stage (P = .005). The DFS (P = .005) and OS (P = .015) were both worse in patients with circ_0018289 high expression compared to patients with circ_0018289 low expression. Meanwhile, in patients with circ_0018289 high expression, DFS and OS were the longest in patients with high+ expression followed by patients with high++ expression, and the shortest in patients with high+++ expression. Moreover, circ_0018289 high expression could independently predict worse DFS in the total cervical cancer patients (P = .042). CONCLUSION: Circ_0018289 could serve as a potential disease monitoring and prognostic biomarker in cervical cancer patients. |
format | Online Article Text |
id | pubmed-7439420 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74394202020-08-21 A potential disease monitoring and prognostic biomarker in cervical cancer patients: The clinical application of circular RNA_0018289 He, Jing Lv, Xin Zeng, Zhen J Clin Lab Anal Research Articles OBJECTIVE: This study aimed to investigate the tumor circular RNA_0018289 (circ_0018289) expression and its correlation with clinical characteristics as well as survival profiles in cervical cancer patients. METHODS: A hundred and ninety‐two cervical cancer patients who received surgical resection were recruited in this prospective study. Tumor tissue and paired adjacent tissue were obtained during the surgery, in which circ_0018289 expression was detected by reverse transcription quantitative polymerase chain reaction. Disease‐free survival (DFS) and overall survival (OS) were recorded. RESULTS: Circ_0018289 expression was upregulated in tumor tissue compared with paired adjacent tissue (P < .001), and receiver operative characteristic curve disclosed its good value for separating tumor tissue from adjacent tissue with an area under curve of 0.907 (95% CI: 0.879‐0.935). Additionally, tumor circ_0018289 expression was positively associated with tumor size (P = .009), lymph node metastasis (P = .005) and Federation International of Gynecology and Obstetrics stage (P = .005). The DFS (P = .005) and OS (P = .015) were both worse in patients with circ_0018289 high expression compared to patients with circ_0018289 low expression. Meanwhile, in patients with circ_0018289 high expression, DFS and OS were the longest in patients with high+ expression followed by patients with high++ expression, and the shortest in patients with high+++ expression. Moreover, circ_0018289 high expression could independently predict worse DFS in the total cervical cancer patients (P = .042). CONCLUSION: Circ_0018289 could serve as a potential disease monitoring and prognostic biomarker in cervical cancer patients. John Wiley and Sons Inc. 2020-04-22 /pmc/articles/PMC7439420/ /pubmed/32320103 http://dx.doi.org/10.1002/jcla.23340 Text en © 2020 The Authors. Journal of Clinical Laboratory Analysis Published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Articles He, Jing Lv, Xin Zeng, Zhen A potential disease monitoring and prognostic biomarker in cervical cancer patients: The clinical application of circular RNA_0018289 |
title | A potential disease monitoring and prognostic biomarker in cervical cancer patients: The clinical application of circular RNA_0018289 |
title_full | A potential disease monitoring and prognostic biomarker in cervical cancer patients: The clinical application of circular RNA_0018289 |
title_fullStr | A potential disease monitoring and prognostic biomarker in cervical cancer patients: The clinical application of circular RNA_0018289 |
title_full_unstemmed | A potential disease monitoring and prognostic biomarker in cervical cancer patients: The clinical application of circular RNA_0018289 |
title_short | A potential disease monitoring and prognostic biomarker in cervical cancer patients: The clinical application of circular RNA_0018289 |
title_sort | potential disease monitoring and prognostic biomarker in cervical cancer patients: the clinical application of circular rna_0018289 |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439420/ https://www.ncbi.nlm.nih.gov/pubmed/32320103 http://dx.doi.org/10.1002/jcla.23340 |
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