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A potential disease monitoring and prognostic biomarker in cervical cancer patients: The clinical application of circular RNA_0018289

OBJECTIVE: This study aimed to investigate the tumor circular RNA_0018289 (circ_0018289) expression and its correlation with clinical characteristics as well as survival profiles in cervical cancer patients. METHODS: A hundred and ninety‐two cervical cancer patients who received surgical resection w...

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Detalles Bibliográficos
Autores principales: He, Jing, Lv, Xin, Zeng, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439420/
https://www.ncbi.nlm.nih.gov/pubmed/32320103
http://dx.doi.org/10.1002/jcla.23340
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author He, Jing
Lv, Xin
Zeng, Zhen
author_facet He, Jing
Lv, Xin
Zeng, Zhen
author_sort He, Jing
collection PubMed
description OBJECTIVE: This study aimed to investigate the tumor circular RNA_0018289 (circ_0018289) expression and its correlation with clinical characteristics as well as survival profiles in cervical cancer patients. METHODS: A hundred and ninety‐two cervical cancer patients who received surgical resection were recruited in this prospective study. Tumor tissue and paired adjacent tissue were obtained during the surgery, in which circ_0018289 expression was detected by reverse transcription quantitative polymerase chain reaction. Disease‐free survival (DFS) and overall survival (OS) were recorded. RESULTS: Circ_0018289 expression was upregulated in tumor tissue compared with paired adjacent tissue (P < .001), and receiver operative characteristic curve disclosed its good value for separating tumor tissue from adjacent tissue with an area under curve of 0.907 (95% CI: 0.879‐0.935). Additionally, tumor circ_0018289 expression was positively associated with tumor size (P = .009), lymph node metastasis (P = .005) and Federation International of Gynecology and Obstetrics stage (P = .005). The DFS (P = .005) and OS (P = .015) were both worse in patients with circ_0018289 high expression compared to patients with circ_0018289 low expression. Meanwhile, in patients with circ_0018289 high expression, DFS and OS were the longest in patients with high+ expression followed by patients with high++ expression, and the shortest in patients with high+++ expression. Moreover, circ_0018289 high expression could independently predict worse DFS in the total cervical cancer patients (P = .042). CONCLUSION: Circ_0018289 could serve as a potential disease monitoring and prognostic biomarker in cervical cancer patients.
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spelling pubmed-74394202020-08-21 A potential disease monitoring and prognostic biomarker in cervical cancer patients: The clinical application of circular RNA_0018289 He, Jing Lv, Xin Zeng, Zhen J Clin Lab Anal Research Articles OBJECTIVE: This study aimed to investigate the tumor circular RNA_0018289 (circ_0018289) expression and its correlation with clinical characteristics as well as survival profiles in cervical cancer patients. METHODS: A hundred and ninety‐two cervical cancer patients who received surgical resection were recruited in this prospective study. Tumor tissue and paired adjacent tissue were obtained during the surgery, in which circ_0018289 expression was detected by reverse transcription quantitative polymerase chain reaction. Disease‐free survival (DFS) and overall survival (OS) were recorded. RESULTS: Circ_0018289 expression was upregulated in tumor tissue compared with paired adjacent tissue (P < .001), and receiver operative characteristic curve disclosed its good value for separating tumor tissue from adjacent tissue with an area under curve of 0.907 (95% CI: 0.879‐0.935). Additionally, tumor circ_0018289 expression was positively associated with tumor size (P = .009), lymph node metastasis (P = .005) and Federation International of Gynecology and Obstetrics stage (P = .005). The DFS (P = .005) and OS (P = .015) were both worse in patients with circ_0018289 high expression compared to patients with circ_0018289 low expression. Meanwhile, in patients with circ_0018289 high expression, DFS and OS were the longest in patients with high+ expression followed by patients with high++ expression, and the shortest in patients with high+++ expression. Moreover, circ_0018289 high expression could independently predict worse DFS in the total cervical cancer patients (P = .042). CONCLUSION: Circ_0018289 could serve as a potential disease monitoring and prognostic biomarker in cervical cancer patients. John Wiley and Sons Inc. 2020-04-22 /pmc/articles/PMC7439420/ /pubmed/32320103 http://dx.doi.org/10.1002/jcla.23340 Text en © 2020 The Authors. Journal of Clinical Laboratory Analysis Published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
He, Jing
Lv, Xin
Zeng, Zhen
A potential disease monitoring and prognostic biomarker in cervical cancer patients: The clinical application of circular RNA_0018289
title A potential disease monitoring and prognostic biomarker in cervical cancer patients: The clinical application of circular RNA_0018289
title_full A potential disease monitoring and prognostic biomarker in cervical cancer patients: The clinical application of circular RNA_0018289
title_fullStr A potential disease monitoring and prognostic biomarker in cervical cancer patients: The clinical application of circular RNA_0018289
title_full_unstemmed A potential disease monitoring and prognostic biomarker in cervical cancer patients: The clinical application of circular RNA_0018289
title_short A potential disease monitoring and prognostic biomarker in cervical cancer patients: The clinical application of circular RNA_0018289
title_sort potential disease monitoring and prognostic biomarker in cervical cancer patients: the clinical application of circular rna_0018289
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439420/
https://www.ncbi.nlm.nih.gov/pubmed/32320103
http://dx.doi.org/10.1002/jcla.23340
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