Elevated ACE-2 expression in the olfactory neuroepithelium: implications for anosmia and upper respiratory SARS-CoV-2 entry and replication

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ACE2 protein is expressed at high levels in the human olfactory epithelium relative to upper airway epithelial cells. This may explain COVID-19-associated olfactory dysfunction, and suggests a SARS-CoV-2 reservoir site and potential intranasal therapy. https://bit.ly/3hxT0qm

Detalles Bibliográficos
Autores principales: Chen, Mengfei, Shen, Wenjuan, Rowan, Nicholas R., Kulaga, Heather, Hillel, Alexander, Ramanathan, Murugappan, Lane, Andrew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2020
Materias:
Agora
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439429/
https://www.ncbi.nlm.nih.gov/pubmed/32817004
http://dx.doi.org/10.1183/13993003.01948-2020
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author Chen, Mengfei
Shen, Wenjuan
Rowan, Nicholas R.
Kulaga, Heather
Hillel, Alexander
Ramanathan, Murugappan
Lane, Andrew P.
author_facet Chen, Mengfei
Shen, Wenjuan
Rowan, Nicholas R.
Kulaga, Heather
Hillel, Alexander
Ramanathan, Murugappan
Lane, Andrew P.
author_sort Chen, Mengfei
collection PubMed
description ACE2 protein is expressed at high levels in the human olfactory epithelium relative to upper airway epithelial cells. This may explain COVID-19-associated olfactory dysfunction, and suggests a SARS-CoV-2 reservoir site and potential intranasal therapy. https://bit.ly/3hxT0qm
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spelling pubmed-74394292020-08-25 Elevated ACE-2 expression in the olfactory neuroepithelium: implications for anosmia and upper respiratory SARS-CoV-2 entry and replication Chen, Mengfei Shen, Wenjuan Rowan, Nicholas R. Kulaga, Heather Hillel, Alexander Ramanathan, Murugappan Lane, Andrew P. Eur Respir J Agora ACE2 protein is expressed at high levels in the human olfactory epithelium relative to upper airway epithelial cells. This may explain COVID-19-associated olfactory dysfunction, and suggests a SARS-CoV-2 reservoir site and potential intranasal therapy. https://bit.ly/3hxT0qm European Respiratory Society 2020-09-24 /pmc/articles/PMC7439429/ /pubmed/32817004 http://dx.doi.org/10.1183/13993003.01948-2020 Text en Copyright ©ERS 2020 https://creativecommons.org/licenses/by-nc/4.0/This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.
spellingShingle Agora
Chen, Mengfei
Shen, Wenjuan
Rowan, Nicholas R.
Kulaga, Heather
Hillel, Alexander
Ramanathan, Murugappan
Lane, Andrew P.
Elevated ACE-2 expression in the olfactory neuroepithelium: implications for anosmia and upper respiratory SARS-CoV-2 entry and replication
title Elevated ACE-2 expression in the olfactory neuroepithelium: implications for anosmia and upper respiratory SARS-CoV-2 entry and replication
title_full Elevated ACE-2 expression in the olfactory neuroepithelium: implications for anosmia and upper respiratory SARS-CoV-2 entry and replication
title_fullStr Elevated ACE-2 expression in the olfactory neuroepithelium: implications for anosmia and upper respiratory SARS-CoV-2 entry and replication
title_full_unstemmed Elevated ACE-2 expression in the olfactory neuroepithelium: implications for anosmia and upper respiratory SARS-CoV-2 entry and replication
title_short Elevated ACE-2 expression in the olfactory neuroepithelium: implications for anosmia and upper respiratory SARS-CoV-2 entry and replication
title_sort elevated ace-2 expression in the olfactory neuroepithelium: implications for anosmia and upper respiratory sars-cov-2 entry and replication
topic Agora
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439429/
https://www.ncbi.nlm.nih.gov/pubmed/32817004
http://dx.doi.org/10.1183/13993003.01948-2020
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