Cargando…

Elevated ACE-2 expression in the olfactory neuroepithelium: implications for anosmia and upper respiratory SARS-CoV-2 entry and replication

Mostrar otras versiones (1)

ACE2 protein is expressed at high levels in the human olfactory epithelium relative to upper airway epithelial cells. This may explain COVID-19-associated olfactory dysfunction, and suggests a SARS-CoV-2 reservoir site and potential intranasal therapy. https://bit.ly/3hxT0qm

Detalles Bibliográficos
Autores principales:	Chen, Mengfei, Shen, Wenjuan, Rowan, Nicholas R., Kulaga, Heather, Hillel, Alexander, Ramanathan, Murugappan, Lane, Andrew P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	European Respiratory Society 2020
Materias:	Agora
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439429/ https://www.ncbi.nlm.nih.gov/pubmed/32817004 http://dx.doi.org/10.1183/13993003.01948-2020

Ejemplares similares

Elevated ACE2 expression in the olfactory neuroepithelium: implications for anosmia and upper respiratory SARS-CoV-2 entry and replication
por: Chen, Mengfei, et al.
Publicado: (2020)

Increased expression of ACE2, the SARS-CoV-2 entry receptor, in alveolar and bronchial epithelium of smokers and COPD subjects
por: Jacobs, Merel, et al.
Publicado: (2020)

Smoking, ACE-2 and COVID-19: ongoing controversies
por: Leung, Janice M., et al.
Publicado: (2020)

COVID-19 and nicotine as a mediator of ACE-2
por: Leung, Janice M., et al.
Publicado: (2020)

Could the smoking gun in the fight against COVID-19 be the (rh)ACE-2?
por: Lutchman, Dhamend
Publicado: (2020)

ACE-2 expression in the small airway epithelia of smokers and COPD patients: implications for COVID-19
por: Leung, Janice M., et al.
Publicado: (2020)

Plasma ACE2 activity is persistently elevated following SARS-CoV-2 infection: implications for COVID-19 pathogenesis and consequences
por: Patel, Sheila K., et al.
Publicado: (2021)

mTORC1 hyperactivation in lymphangioleiomyomatosis leads to ACE2 upregulation in type II pneumocytes: implications for COVID-19
por: Tang, Yan, et al.
Publicado: (2021)

Evolution of nasal and olfactory infection characteristics of SARS-CoV-2 variants
por: Chen, Mengfei, et al.
Publicado: (2022)

A Heparan-Dependent Herpesvirus Targets the Olfactory Neuroepithelium for Host Entry
por: Milho, Ricardo, et al.
Publicado: (2012)

SARS-CoV-2 Receptors and Entry Genes Are Expressed in the Human Olfactory Neuroepithelium and Brain
por: Fodoulian, Leon, et al.
Publicado: (2020)

Herpes Simplex Virus 1 Targets the Murine Olfactory Neuroepithelium for Host Entry
por: Shivkumar, Maitreyi, et al.
Publicado: (2013)

Exposure to Particulate Matter Air Pollution and Anosmia
por: Zhang, Zhenyu, et al.
Publicado: (2021)

Mechanistic Understanding of the Olfactory Neuroepithelium Involvement Leading to Short-Term Anosmia in COVID-19 Using the Adverse Outcome Pathway Framework
por: Shahbaz, Muhammad Ali, et al.
Publicado: (2022)

Limited role for bronchoalveolar lavage to exclude COVID-19 after negative upper respiratory tract swabs: a multicentre study
por: Geri, Pietro, et al.
Publicado: (2020)

The Role of ACE2 Receptors of the Olfactory System in Anosmia in COVID-19: An Overview
por: Nasr, Mohammad Javad, et al.
Publicado: (2021)

P(aO(2))/F(IO(2)) ratio: the mismeasure of oxygenation in COVID-19
por: Tobin, Martin J., et al.
Publicado: (2021)

Acute respiratory distress syndrome is associated with impaired alveolar macrophage efferocytosis
por: Mahida, Rahul Y., et al.
Publicado: (2021)

Impact of baseline patient characteristics on dupilumab efficacy in type 2 asthma
por: Busse, William W., et al.
Publicado: (2021)

Hyperventilation as one of the mechanisms of persistent dyspnoea in SARS-CoV-2 survivors
por: Motiejunaite, Justina, et al.
Publicado: (2021)

Impact of the SARS-CoV-2 epidemic on tuberculosis treatment outcome in Northern Italy
por: Magro, Paola, et al.
Publicado: (2020)

Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2
por: Yang, Hai-Jun, et al.
Publicado: (2020)

COVID-19 and vaping: risk for increased susceptibility to SARS-CoV-2 infection?
por: McAlinden, Kielan Darcy, et al.
Publicado: (2020)

Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2
por: Du, Rong-Hui, et al.
Publicado: (2020)

Autoimmunity to annexin A2 predicts mortality among hospitalised COVID-19 patients
por: Zuniga, Marisol, et al.
Publicado: (2021)

Socioeconomic correlates of SARS-CoV-2 and influenza H1N1 outbreaks
por: Kaiser, Jan Christian, et al.
Publicado: (2020)

Functional characteristics of patients with SARS-CoV-2 pneumonia at 30 days post-infection
por: Frija-Masson, Justine, et al.
Publicado: (2020)

Saliva molecular testing for SARS-CoV-2: simplifying the diagnosis without losing accuracy
por: Saluzzo, Francesca, et al.
Publicado: (2021)

Asthma, COPD and SARS-CoV-2 infection (COVID-19): potential mechanistic insights
por: Wark, Peter A.B., et al.
Publicado: (2021)

Comparison of severity scores for COVID-19 patients with pneumonia: a retrospective study
por: Fan, Guohui, et al.
Publicado: (2020)

Distinct features of SARS-CoV-2-specific IgA response in COVID-19 patients
por: Yu, Hai-qiong, et al.
Publicado: (2020)

Residual symptoms and lower lung function in patients recovering from SARS-CoV-2 infection
por: Trinkmann, Frederik, et al.
Publicado: (2021)

SARS-CoV-2 disrupts clinical research: the role of a rare disease-specific trial network
por: van Koningsbruggen-Rietschel, Silke, et al.
Publicado: (2020)

Utility and safety of bronchoscopy during the SARS-CoV-2 outbreak in Italy: a retrospective, multicentre study
por: Mondoni, Michele, et al.
Publicado: (2020)

Venous thromboembolism in SARS-CoV-2 patients: only a problem in ventilated ICU patients, or is there more to it?
por: Criel, Maarten, et al.
Publicado: (2020)

SARS-CoV-2 infections in people with primary ciliary dyskinesia: neither frequent, nor particularly severe
por: Pedersen, Eva S.L., et al.
Publicado: (2021)

The association between SARS-CoV-2 RT-PCR cycle threshold and mortality in a community cohort
por: Waudby-West, Rupert, et al.
Publicado: (2021)

Characteristics and outcomes of health and social care workers testing positive for SARS-CoV-2 in the Tayside region of Scotland
por: Siddiqui, Moneeza K., et al.
Publicado: (2020)

Does chemotherapy reactivate SARS-CoV-2 in cancer patients recovered from prior COVID-19 infection?
por: Bi, Jianping, et al.
Publicado: (2020)

Responding to SARS-CoV-2 in South Africa: what can we learn from drug-resistant tuberculosis?
por: Ndjeka, Norbert, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_0ph1252iq9mk6p6gjejmq99frk