A Genome-Wide CRISPR/Cas9 Screen Reveals that Riboflavin Regulates Hydrogen Peroxide Entry into HAP1 Cells

Extracellular hydrogen peroxide can induce oxidative stress, which can cause cell death if unresolved. However, the cellular mediators of H(2)O(2)-induced cell death are unknown. We determined that H(2)O(2)-induced cytotoxicity is an iron-dependent process in HAP1 cells and conducted a CRISPR/Cas9-b...

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Detalles Bibliográficos
Autores principales: Chidawanyika, Tamutenda, Mark, Kenneth M. K., Supattapone, Surachai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439486/
https://www.ncbi.nlm.nih.gov/pubmed/32788383
http://dx.doi.org/10.1128/mBio.01704-20

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