IL-10–producing Tfh cells accumulate with age and link inflammation with age-related immune suppression

Aging results in profound immune dysfunction, resulting in the decline of vaccine responsiveness previously attributed to irreversible defects in the immune system. In addition to increased interleukin-6 (IL-6), we found aged mice exhibit increased systemic IL-10 that requires forkhead box P3–negati...

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Detalles Bibliográficos
Autores principales: Almanan, Maha, Raynor, Jana, Ogunsulire, Ireti, Malyshkina, Anna, Mukherjee, Shibabrata, Hummel, Sarah A., Ingram, Jennifer T., Saini, Ankur, Xie, Markus M., Alenghat, Theresa, Way, Sing Sing, Deepe, George S., Divanovic, Senad, Singh, Harinder, Miraldi, Emily, Zajac, Allan J., Dent, Alexander L., Hölscher, Christoph, Chougnet, Claire, Hildeman, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439492/
https://www.ncbi.nlm.nih.gov/pubmed/32832688
http://dx.doi.org/10.1126/sciadv.abb0806

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