RACK7 recognizes H3.3G34R mutation to suppress expression of MHC class II complex components and their delivery pathway in pediatric glioblastoma

Histone H3 point mutations have been identified in incurable pediatric brain cancers, but the mechanisms through which these mutations drive tumorigenesis are incompletely understood. Here, we provide evidence that RACK7 (ZMYND8) recognizes the histone H3.3 patient mutation (H3.3G34R) in vitro and i...

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Detalles Bibliográficos
Autores principales: Jiao, Fangfang, Li, Ze, He, Chen, Xu, Wenqi, Yang, Gensheng, Liu, Tingting, Shen, Hongjie, Cai, Jiajun, Anastas, Jamie N., Mao, Ying, Yu, Yongchun, Lan, Fei, Shi, Yujiang Geno, Jones, Chris, Xu, Yanhui, Baker, Suzanne J., Shi, Yang, Guo, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439511/
https://www.ncbi.nlm.nih.gov/pubmed/32832624
http://dx.doi.org/10.1126/sciadv.aba2113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439511/
https://www.ncbi.nlm.nih.gov/pubmed/32832624
http://dx.doi.org/10.1126/sciadv.aba2113

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