PRDM8 reveals aberrant DNA methylation in aging syndromes and is relevant for hematopoietic and neuronal differentiation

BACKGROUND: Dyskeratosis congenita (DKC) and idiopathic aplastic anemia (AA) are bone marrow failure syndromes that share characteristics of premature aging with severe telomere attrition. Aging is also reflected by DNA methylation changes, which can be utilized to predict donor age. There is eviden...

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Detalles Bibliográficos
Autores principales: Cypris, Olivia, Eipel, Monika, Franzen, Julia, Rösseler, Corinna, Tharmapalan, Vithurithra, Kuo, Chao-Chung, Vieri, Margherita, Nikolić, Miloš, Kirschner, Martin, Brümmendorf, Tim H., Zenke, Martin, Lampert, Angelika, Beier, Fabian, Wagner, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439574/
https://www.ncbi.nlm.nih.gov/pubmed/32819411
http://dx.doi.org/10.1186/s13148-020-00914-5

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