β-Catenin safeguards the ground state of mousepluripotency by strengthening the robustness of the transcriptional apparatus

Mouse embryonic stem cells cultured with MEK (mitogen-activated protein kinase kinase) and GSK3 (glycogen synthase kinase 3) inhibitors (2i) more closely resemble the inner cell mass of preimplantation blastocysts than those cultured with SL [serum/leukemia inhibitory factor (LIF)]. The transcriptio...

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Detalles Bibliográficos
Autores principales: Zhang, Meng, Lai, Yiwei, Krupalnik, Vladislav, Guo, Pengcheng, Guo, Xiangpeng, Zhou, Jianguo, Xu, Yan, Yu, Zhijun, Liu, Longqi, Jiang, Ao, Li, Wenjuan, Abdul, Mazid Md., Ma, Gang, Li, Na, Fu, Xiuling, Lv, Yuan, Jiang, Mengling, Tariq, Muqddas, Kanwal, Shahzina, Liu, Hao, Xu, Xueting, Zhang, Hui, Huang, Yinghua, Wang, Lulu, Chen, Shuhan, Babarinde, Isaac A., Luo, Zhiwei, Wang, Dongye, Zhou, Tiantian, Ward, Carl, He, Minghui, Ibañez, David P., Li, Yunpan, Zhou, Jiajian, Yuan, Jie, Feng, Yayan, Arumugam, Karthik, Di Vicino, Umberto, Bao, Xichen, Wu, Guangming, Schambach, Axel, Wang, Huating, Sun, Hao, Gao, Fei, Qin, Baoming, Hutchins, Andrew P., Doble, Bradley W., Hartmann, Christine, Cosma, Maria Pia, Qin, Yan, Xu, Guo-Liang, Chen, Runsheng, Volpe, Giacomo, Chen, Liang, Hanna, Jacob H., Esteban, Miguel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439582/
https://www.ncbi.nlm.nih.gov/pubmed/32832621
http://dx.doi.org/10.1126/sciadv.aba1593

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