Codelivery of CRISPR-Cas9 and chlorin e6 for spatially controlled tumor-specific gene editing with synergistic drug effects

Controlled release of CRISPR-Cas9 ribonucleoprotein (RNP) and codelivery with other drugs remain a challenge. We demonstrate controlled release of CRISPR-Cas9 RNP and codelivery with antitumor photosensitizer chlorin e6 (Ce6) using near-infrared (NIR)– and reducing agent–responsive nanoparticles in...

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Detalles Bibliográficos
Autores principales: Deng, Shaohui, Li, Xiaoxia, Liu, Shuang, Chen, Jifeng, Li, Mingqiang, Chew, Sing Yian, Leong, Kam W., Cheng, Du
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439618/
https://www.ncbi.nlm.nih.gov/pubmed/32832641
http://dx.doi.org/10.1126/sciadv.abb4005

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