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Animal and translational models of SARS-CoV-2 infection and COVID-19
COVID-19 is causing a major once-in-a-century global pandemic. The scientific and clinical community is in a race to define and develop effective preventions and treatments. The major features of disease are described but clinical trials have been hampered by competing interests, small scale, lack o...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
© Society for Mucosal Immunology. Published by Elsevier Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439637/ https://www.ncbi.nlm.nih.gov/pubmed/32820248 http://dx.doi.org/10.1038/s41385-020-00340-z |
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author | Johansen, M.D. Irving, A. Montagutelli, X. Tate, M.D. Rudloff, I. Nold, M.F. Hansbro, N.G. Kim, R.Y. Donovan, C. Liu, G. Faiz, A. Short, K.R. Lyons, J.G. McCaughan, G.W. Gorrell, M.D. Cole, A. Moreno, C. Couteur, D. Hesselson, D. Triccas, J. Neely, G.G. Gamble, J.R. Simpson, S.J. Saunders, B.M. Oliver, B.G. Britton, W.J. Wark, P.A. Nold-Petry, C.A. Hansbro, P.M. |
author_facet | Johansen, M.D. Irving, A. Montagutelli, X. Tate, M.D. Rudloff, I. Nold, M.F. Hansbro, N.G. Kim, R.Y. Donovan, C. Liu, G. Faiz, A. Short, K.R. Lyons, J.G. McCaughan, G.W. Gorrell, M.D. Cole, A. Moreno, C. Couteur, D. Hesselson, D. Triccas, J. Neely, G.G. Gamble, J.R. Simpson, S.J. Saunders, B.M. Oliver, B.G. Britton, W.J. Wark, P.A. Nold-Petry, C.A. Hansbro, P.M. |
author_sort | Johansen, M.D. |
collection | PubMed |
description | COVID-19 is causing a major once-in-a-century global pandemic. The scientific and clinical community is in a race to define and develop effective preventions and treatments. The major features of disease are described but clinical trials have been hampered by competing interests, small scale, lack of defined patient cohorts and defined readouts. What is needed now is head-to-head comparison of existing drugs, testing of safety including in the background of predisposing chronic diseases, and the development of new and targeted preventions and treatments. This is most efficiently achieved using representative animal models of primary infection including in the background of chronic disease with validation of findings in primary human cells and tissues. We explore and discuss the diverse animal, cell and tissue models that are being used and developed and collectively recapitulate many critical aspects of disease manifestation in humans to develop and test new preventions and treatments. |
format | Online Article Text |
id | pubmed-7439637 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | © Society for Mucosal Immunology. Published by Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74396372020-08-21 Animal and translational models of SARS-CoV-2 infection and COVID-19 Johansen, M.D. Irving, A. Montagutelli, X. Tate, M.D. Rudloff, I. Nold, M.F. Hansbro, N.G. Kim, R.Y. Donovan, C. Liu, G. Faiz, A. Short, K.R. Lyons, J.G. McCaughan, G.W. Gorrell, M.D. Cole, A. Moreno, C. Couteur, D. Hesselson, D. Triccas, J. Neely, G.G. Gamble, J.R. Simpson, S.J. Saunders, B.M. Oliver, B.G. Britton, W.J. Wark, P.A. Nold-Petry, C.A. Hansbro, P.M. Mucosal Immunol Review-Article COVID-19 is causing a major once-in-a-century global pandemic. The scientific and clinical community is in a race to define and develop effective preventions and treatments. The major features of disease are described but clinical trials have been hampered by competing interests, small scale, lack of defined patient cohorts and defined readouts. What is needed now is head-to-head comparison of existing drugs, testing of safety including in the background of predisposing chronic diseases, and the development of new and targeted preventions and treatments. This is most efficiently achieved using representative animal models of primary infection including in the background of chronic disease with validation of findings in primary human cells and tissues. We explore and discuss the diverse animal, cell and tissue models that are being used and developed and collectively recapitulate many critical aspects of disease manifestation in humans to develop and test new preventions and treatments. © Society for Mucosal Immunology. Published by Elsevier Inc. 2020-11 2022-12-31 /pmc/articles/PMC7439637/ /pubmed/32820248 http://dx.doi.org/10.1038/s41385-020-00340-z Text en Copyright © 2020 © Society for Mucosal Immunology. Published by Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Review-Article Johansen, M.D. Irving, A. Montagutelli, X. Tate, M.D. Rudloff, I. Nold, M.F. Hansbro, N.G. Kim, R.Y. Donovan, C. Liu, G. Faiz, A. Short, K.R. Lyons, J.G. McCaughan, G.W. Gorrell, M.D. Cole, A. Moreno, C. Couteur, D. Hesselson, D. Triccas, J. Neely, G.G. Gamble, J.R. Simpson, S.J. Saunders, B.M. Oliver, B.G. Britton, W.J. Wark, P.A. Nold-Petry, C.A. Hansbro, P.M. Animal and translational models of SARS-CoV-2 infection and COVID-19 |
title | Animal and translational models of SARS-CoV-2 infection and COVID-19 |
title_full | Animal and translational models of SARS-CoV-2 infection and COVID-19 |
title_fullStr | Animal and translational models of SARS-CoV-2 infection and COVID-19 |
title_full_unstemmed | Animal and translational models of SARS-CoV-2 infection and COVID-19 |
title_short | Animal and translational models of SARS-CoV-2 infection and COVID-19 |
title_sort | animal and translational models of sars-cov-2 infection and covid-19 |
topic | Review-Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439637/ https://www.ncbi.nlm.nih.gov/pubmed/32820248 http://dx.doi.org/10.1038/s41385-020-00340-z |
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