Cell identity and nucleo-mitochondrial genetic context modulate OXPHOS performance and determine somatic heteroplasmy dynamics

Heteroplasmy, multiple variants of mitochondrial DNA (mtDNA) in the same cytoplasm, may be naturally generated by mutations but is counteracted by a genetic mtDNA bottleneck during oocyte development. Engineered heteroplasmic mice with nonpathological mtDNA variants reveal a nonrandom tissue-specifi...

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Detalles Bibliográficos
Autores principales: Lechuga-Vieco, Ana Victoria, Latorre-Pellicer, Ana, Johnston, Iain G., Prota, Gennaro, Gileadi, Uzi, Justo-Méndez, Raquel, Acín-Pérez, Rebeca, Martínez-de-Mena, Raquel, Fernández-Toro, Jose María, Jimenez-Blasco, Daniel, Mora, Alfonso, Nicolás-Ávila, Jose A., Santiago, Demetrio J., Priori, Silvia G., Bolaños, Juan Pedro, Sabio, Guadalupe, Criado, Luis Miguel, Ruíz-Cabello, Jesús, Cerundolo, Vincenzo, Jones, Nick S., Enríquez, José Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439646/
https://www.ncbi.nlm.nih.gov/pubmed/32832682
http://dx.doi.org/10.1126/sciadv.aba5345

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