Enantioselective synthesis of isochromans and tetrahydroisoquinolines by C–H insertion of donor/donor carbenes

Reports of C–H insertions forming six-membered rings containing heteroatoms are rare due to Stevens rearrangements occurring after nucleophilic attack on the carbene by a heteroatom. Using donor/donor carbenes and Rh(2)(R-PTAD)(4) as a catalyst, we have synthesized a collection of isochroman substra...

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Detalles Bibliográficos
Autores principales: Nickerson, Leslie A., Bergstrom, Benjamin D., Gao, Mingchun, Shiue, Yuan-Shin, Laconsay, Croix J., Culberson, Matthew R., Knauss, Walker A., Fettinger, James C., Tantillo, Dean J., Shaw, Jared T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439777/
https://www.ncbi.nlm.nih.gov/pubmed/32874491
http://dx.doi.org/10.1039/c9sc05111b

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