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A comprehensive strategy for the early treatment of COVID-19 with azithromycin/hydroxychloroquine and/or corticosteroids: Results of a retrospective observational study in the French overseas department of Réunion Island
BACKGROUND: This study aimed to evaluate the prognosis of COVID-19 patients in Reunion Island, with a particular focus on the management of patients with hypoxemic pneumonia. METHODS: This retrospective observational study was conducted from 11 March to 17 April 2020 at the only hospital authorized...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Authors. Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439827/ https://www.ncbi.nlm.nih.gov/pubmed/32828896 http://dx.doi.org/10.1016/j.jgar.2020.08.001 |
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author | Dubernet, Arthur Larsen, Kevin Masse, Laurie Allyn, Jérôme Foch, Emilie Bruneau, Lea Maillot, Adrien Lagrange-Xelot, Marie Thomas, Vincent Jaffar-Bandjee, Marie-Christine Gauzere, Loraine Raffray, Loic Borsu, Karine Dibernardo, Servane Renaud, Stéphane André, Michel Moreau, Diane Jabot, Julien Coolen-Allou, Nathalie Allou, Nicolas |
author_facet | Dubernet, Arthur Larsen, Kevin Masse, Laurie Allyn, Jérôme Foch, Emilie Bruneau, Lea Maillot, Adrien Lagrange-Xelot, Marie Thomas, Vincent Jaffar-Bandjee, Marie-Christine Gauzere, Loraine Raffray, Loic Borsu, Karine Dibernardo, Servane Renaud, Stéphane André, Michel Moreau, Diane Jabot, Julien Coolen-Allou, Nathalie Allou, Nicolas |
author_sort | Dubernet, Arthur |
collection | PubMed |
description | BACKGROUND: This study aimed to evaluate the prognosis of COVID-19 patients in Reunion Island, with a particular focus on the management of patients with hypoxemic pneumonia. METHODS: This retrospective observational study was conducted from 11 March to 17 April 2020 at the only hospital authorized to manage patients with COVID-19 in Reunion Island. RESULTS: Over the study period, 164 out of 398 patients (41.2%) infected with COVID-19 were admitted to Félix Guyon University Hospital. Of these, 36 (22%) developed hypoxemic pneumonia. Patients with hypoxemic pneumonia were aged 66 [56–77] years, 69% were male and 33% had hypertension. Ten patients (27.8%) were hospitalized in intensive care unit (ICU). Hydroxychloroquine/azithromycin treatment was associated with a lower ICU admission rate (P = 0.008). None of the 6 patients treated with corticosteroids were hospitalized in ICU (P = 0.16). There were no deaths at follow up (minimum 80 days). CONCLUSIONS: Despite the risk profile of COVID-19 patients with severe hypoxemic pneumonia, the mortality rate of the disease in Reunion Island was 0%. This may be due to the care bundle used in our hospital (early hospitalisation, treatment with hydroxychloroquine/azithromycin and/or corticosteroids, non-invasive respiratory support, etc). |
format | Online Article Text |
id | pubmed-7439827 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Authors. Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74398272020-08-21 A comprehensive strategy for the early treatment of COVID-19 with azithromycin/hydroxychloroquine and/or corticosteroids: Results of a retrospective observational study in the French overseas department of Réunion Island Dubernet, Arthur Larsen, Kevin Masse, Laurie Allyn, Jérôme Foch, Emilie Bruneau, Lea Maillot, Adrien Lagrange-Xelot, Marie Thomas, Vincent Jaffar-Bandjee, Marie-Christine Gauzere, Loraine Raffray, Loic Borsu, Karine Dibernardo, Servane Renaud, Stéphane André, Michel Moreau, Diane Jabot, Julien Coolen-Allou, Nathalie Allou, Nicolas J Glob Antimicrob Resist Short Communication BACKGROUND: This study aimed to evaluate the prognosis of COVID-19 patients in Reunion Island, with a particular focus on the management of patients with hypoxemic pneumonia. METHODS: This retrospective observational study was conducted from 11 March to 17 April 2020 at the only hospital authorized to manage patients with COVID-19 in Reunion Island. RESULTS: Over the study period, 164 out of 398 patients (41.2%) infected with COVID-19 were admitted to Félix Guyon University Hospital. Of these, 36 (22%) developed hypoxemic pneumonia. Patients with hypoxemic pneumonia were aged 66 [56–77] years, 69% were male and 33% had hypertension. Ten patients (27.8%) were hospitalized in intensive care unit (ICU). Hydroxychloroquine/azithromycin treatment was associated with a lower ICU admission rate (P = 0.008). None of the 6 patients treated with corticosteroids were hospitalized in ICU (P = 0.16). There were no deaths at follow up (minimum 80 days). CONCLUSIONS: Despite the risk profile of COVID-19 patients with severe hypoxemic pneumonia, the mortality rate of the disease in Reunion Island was 0%. This may be due to the care bundle used in our hospital (early hospitalisation, treatment with hydroxychloroquine/azithromycin and/or corticosteroids, non-invasive respiratory support, etc). The Authors. Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy. 2020-12 2020-08-20 /pmc/articles/PMC7439827/ /pubmed/32828896 http://dx.doi.org/10.1016/j.jgar.2020.08.001 Text en © 2020 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Short Communication Dubernet, Arthur Larsen, Kevin Masse, Laurie Allyn, Jérôme Foch, Emilie Bruneau, Lea Maillot, Adrien Lagrange-Xelot, Marie Thomas, Vincent Jaffar-Bandjee, Marie-Christine Gauzere, Loraine Raffray, Loic Borsu, Karine Dibernardo, Servane Renaud, Stéphane André, Michel Moreau, Diane Jabot, Julien Coolen-Allou, Nathalie Allou, Nicolas A comprehensive strategy for the early treatment of COVID-19 with azithromycin/hydroxychloroquine and/or corticosteroids: Results of a retrospective observational study in the French overseas department of Réunion Island |
title | A comprehensive strategy for the early treatment of COVID-19 with azithromycin/hydroxychloroquine and/or corticosteroids: Results of a retrospective observational study in the French overseas department of Réunion Island |
title_full | A comprehensive strategy for the early treatment of COVID-19 with azithromycin/hydroxychloroquine and/or corticosteroids: Results of a retrospective observational study in the French overseas department of Réunion Island |
title_fullStr | A comprehensive strategy for the early treatment of COVID-19 with azithromycin/hydroxychloroquine and/or corticosteroids: Results of a retrospective observational study in the French overseas department of Réunion Island |
title_full_unstemmed | A comprehensive strategy for the early treatment of COVID-19 with azithromycin/hydroxychloroquine and/or corticosteroids: Results of a retrospective observational study in the French overseas department of Réunion Island |
title_short | A comprehensive strategy for the early treatment of COVID-19 with azithromycin/hydroxychloroquine and/or corticosteroids: Results of a retrospective observational study in the French overseas department of Réunion Island |
title_sort | comprehensive strategy for the early treatment of covid-19 with azithromycin/hydroxychloroquine and/or corticosteroids: results of a retrospective observational study in the french overseas department of réunion island |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439827/ https://www.ncbi.nlm.nih.gov/pubmed/32828896 http://dx.doi.org/10.1016/j.jgar.2020.08.001 |
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