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CMTM6 significantly relates to PD-L1 and predicts the prognosis of gastric cancer patients
BACKGROUND: The CKLF-like MARVEL transmembrane domain containing 6 (CMTM6) is a key regulator of the programed death receptor ligand-1 (PD-L1) protein. However, the usefulness of CMTM6 expression as a prognostic indicator and the relationship between CMTM6 and PD-L1 expression in gastric cancer (GC)...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PeerJ Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439957/ https://www.ncbi.nlm.nih.gov/pubmed/32874775 http://dx.doi.org/10.7717/peerj.9536 |
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author | Li, Xin Chen, Ling Gu, Chuan Sun, Qiaoli Li, Jia |
author_facet | Li, Xin Chen, Ling Gu, Chuan Sun, Qiaoli Li, Jia |
author_sort | Li, Xin |
collection | PubMed |
description | BACKGROUND: The CKLF-like MARVEL transmembrane domain containing 6 (CMTM6) is a key regulator of the programed death receptor ligand-1 (PD-L1) protein. However, the usefulness of CMTM6 expression as a prognostic indicator and the relationship between CMTM6 and PD-L1 expression in gastric cancer (GC) remains unclear. OBJECTIVES: We evaluated the expression and prognostic implications of CMTM6 in GC tissue and its relationship with PD-L1 expression. PATIENTS AND METHODS: The protein expressions of CMTM6 and PD-L1 were detected in 122 cases of postoperative GC tissue using immunohistochemical (IHC) assays. Kaplan–Meier survival analysis was used to calculate the survival probability and a log-rank test was used to compare the survival curves. Univariate and multivariate Cox proportional hazard regression analyses were used to evaluate the clinically-related factors associated with survival. Pearson’s correlation was used to determine the correlation analysis and estimate the statistical significance. The univariate and multivariate logistic regression analyses were used to analyze the relationship between clinically-related factors and PD-L1 expression. RESULTS: Kaplan–Meier survival analysis showed that patients with high CMTM6 expression had shorter overall survival (OS) than those with low expression (P < 0.001). The expression of CMTM6 was an independent risk factor for prognosis in multivariate Cox proportional hazard regression analyses (HR:2.221, CI% [1.36–3.628], P = 0.001). The OS of patients with positively expressed PD-L1 was significantly shorter than those with negatively expressed PD-L1 (P = 0.003). The expression of CMTM6 was significantly related to the positive expression of PD-L1 in gastric cancer tissues (r = 0.186, P = 0.041). The expression of CMTM6 was the independent risk factor for PD-L1 expression in multivariate logistic regression analysis (OR:2.538, CI% [1.128–5.714], P = 0.024). CONCLUSION: CMTM6 expression is significantly related to PD-L1 and may be a useful prognostic indicator and a specific therapeutic target for cancer immunotherapy for GC patients. |
format | Online Article Text |
id | pubmed-7439957 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | PeerJ Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74399572020-08-31 CMTM6 significantly relates to PD-L1 and predicts the prognosis of gastric cancer patients Li, Xin Chen, Ling Gu, Chuan Sun, Qiaoli Li, Jia PeerJ Bioinformatics BACKGROUND: The CKLF-like MARVEL transmembrane domain containing 6 (CMTM6) is a key regulator of the programed death receptor ligand-1 (PD-L1) protein. However, the usefulness of CMTM6 expression as a prognostic indicator and the relationship between CMTM6 and PD-L1 expression in gastric cancer (GC) remains unclear. OBJECTIVES: We evaluated the expression and prognostic implications of CMTM6 in GC tissue and its relationship with PD-L1 expression. PATIENTS AND METHODS: The protein expressions of CMTM6 and PD-L1 were detected in 122 cases of postoperative GC tissue using immunohistochemical (IHC) assays. Kaplan–Meier survival analysis was used to calculate the survival probability and a log-rank test was used to compare the survival curves. Univariate and multivariate Cox proportional hazard regression analyses were used to evaluate the clinically-related factors associated with survival. Pearson’s correlation was used to determine the correlation analysis and estimate the statistical significance. The univariate and multivariate logistic regression analyses were used to analyze the relationship between clinically-related factors and PD-L1 expression. RESULTS: Kaplan–Meier survival analysis showed that patients with high CMTM6 expression had shorter overall survival (OS) than those with low expression (P < 0.001). The expression of CMTM6 was an independent risk factor for prognosis in multivariate Cox proportional hazard regression analyses (HR:2.221, CI% [1.36–3.628], P = 0.001). The OS of patients with positively expressed PD-L1 was significantly shorter than those with negatively expressed PD-L1 (P = 0.003). The expression of CMTM6 was significantly related to the positive expression of PD-L1 in gastric cancer tissues (r = 0.186, P = 0.041). The expression of CMTM6 was the independent risk factor for PD-L1 expression in multivariate logistic regression analysis (OR:2.538, CI% [1.128–5.714], P = 0.024). CONCLUSION: CMTM6 expression is significantly related to PD-L1 and may be a useful prognostic indicator and a specific therapeutic target for cancer immunotherapy for GC patients. PeerJ Inc. 2020-08-17 /pmc/articles/PMC7439957/ /pubmed/32874775 http://dx.doi.org/10.7717/peerj.9536 Text en © 2020 Li et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited. |
spellingShingle | Bioinformatics Li, Xin Chen, Ling Gu, Chuan Sun, Qiaoli Li, Jia CMTM6 significantly relates to PD-L1 and predicts the prognosis of gastric cancer patients |
title | CMTM6 significantly relates to PD-L1 and predicts the prognosis of gastric cancer patients |
title_full | CMTM6 significantly relates to PD-L1 and predicts the prognosis of gastric cancer patients |
title_fullStr | CMTM6 significantly relates to PD-L1 and predicts the prognosis of gastric cancer patients |
title_full_unstemmed | CMTM6 significantly relates to PD-L1 and predicts the prognosis of gastric cancer patients |
title_short | CMTM6 significantly relates to PD-L1 and predicts the prognosis of gastric cancer patients |
title_sort | cmtm6 significantly relates to pd-l1 and predicts the prognosis of gastric cancer patients |
topic | Bioinformatics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439957/ https://www.ncbi.nlm.nih.gov/pubmed/32874775 http://dx.doi.org/10.7717/peerj.9536 |
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