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Effect of changes in serum levels of endogenous hydrogen sulfide on fracture healing: Study protocol clinical trial (SPIRIT compliant)

BACKGROUND: Fracture is a common disease; many factors affect fracture healing. Recent studies have confirmed that hydrogen sulfide (H(2)S) plays an essential role in bone formation, but most of these studies are drawing conclusions based on animal experiment; whether H(2)S could promote fracture he...

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Autores principales: Liao, Feng, Zhu, Zongdong, Xiao, Chengwei, Tan, Bo, Tang, Xiaoming, Wei, Dan, Yuan, Jiabin, Xiang, Xuemei, Hu, Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7440181/
https://www.ncbi.nlm.nih.gov/pubmed/32243406
http://dx.doi.org/10.1097/MD.0000000000019684
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author Liao, Feng
Zhu, Zongdong
Xiao, Chengwei
Tan, Bo
Tang, Xiaoming
Wei, Dan
Yuan, Jiabin
Xiang, Xuemei
Hu, Jiang
author_facet Liao, Feng
Zhu, Zongdong
Xiao, Chengwei
Tan, Bo
Tang, Xiaoming
Wei, Dan
Yuan, Jiabin
Xiang, Xuemei
Hu, Jiang
author_sort Liao, Feng
collection PubMed
description BACKGROUND: Fracture is a common disease; many factors affect fracture healing. Recent studies have confirmed that hydrogen sulfide (H(2)S) plays an essential role in bone formation, but most of these studies are drawing conclusions based on animal experiment; whether H(2)S could promote fracture healing in patients is still unclear. We aim to investigate the change of serum H(2)S in fracture patients, and analyze its effort on fracture healing. METHODS: This is a single-center, prospective cohort study. Patients with spinal or limb fracture will be recruited. Patient's serum and urine will be collected at baseline for examination (serum H(2)S, β-CTX, OC, PINP, 25-OH-VitD(3), S-CTX, urinary calcium, and urinary creatinine). All patients will be followed-up for 24 months in outpatients settings, the image of X-ray or CT will be reviewed and fracture healing will be judged by 2 experienced orthopedic physicians. The difference in serum parameters especially H(2)S will be compared between patients with fracture healed within 9 months and those with fracture unhealed at 9 months. DISCUSSION: Results of the trial could provide insight into influence of H(2)S on fracture healing. ETHICS AND DISSEMINATION: The study was approved by the ethics committee of School of Medicine UESTC & Sichuan Provincial People's Hospital Ethics Committee. All the participants will be asked to provide written informed consent before data collection. The findings of the study will be published in peer-reviewed journals and will be presented at national or international conferences.
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spelling pubmed-74401812020-09-04 Effect of changes in serum levels of endogenous hydrogen sulfide on fracture healing: Study protocol clinical trial (SPIRIT compliant) Liao, Feng Zhu, Zongdong Xiao, Chengwei Tan, Bo Tang, Xiaoming Wei, Dan Yuan, Jiabin Xiang, Xuemei Hu, Jiang Medicine (Baltimore) 6300 BACKGROUND: Fracture is a common disease; many factors affect fracture healing. Recent studies have confirmed that hydrogen sulfide (H(2)S) plays an essential role in bone formation, but most of these studies are drawing conclusions based on animal experiment; whether H(2)S could promote fracture healing in patients is still unclear. We aim to investigate the change of serum H(2)S in fracture patients, and analyze its effort on fracture healing. METHODS: This is a single-center, prospective cohort study. Patients with spinal or limb fracture will be recruited. Patient's serum and urine will be collected at baseline for examination (serum H(2)S, β-CTX, OC, PINP, 25-OH-VitD(3), S-CTX, urinary calcium, and urinary creatinine). All patients will be followed-up for 24 months in outpatients settings, the image of X-ray or CT will be reviewed and fracture healing will be judged by 2 experienced orthopedic physicians. The difference in serum parameters especially H(2)S will be compared between patients with fracture healed within 9 months and those with fracture unhealed at 9 months. DISCUSSION: Results of the trial could provide insight into influence of H(2)S on fracture healing. ETHICS AND DISSEMINATION: The study was approved by the ethics committee of School of Medicine UESTC & Sichuan Provincial People's Hospital Ethics Committee. All the participants will be asked to provide written informed consent before data collection. The findings of the study will be published in peer-reviewed journals and will be presented at national or international conferences. Wolters Kluwer Health 2020-04-03 /pmc/articles/PMC7440181/ /pubmed/32243406 http://dx.doi.org/10.1097/MD.0000000000019684 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 6300
Liao, Feng
Zhu, Zongdong
Xiao, Chengwei
Tan, Bo
Tang, Xiaoming
Wei, Dan
Yuan, Jiabin
Xiang, Xuemei
Hu, Jiang
Effect of changes in serum levels of endogenous hydrogen sulfide on fracture healing: Study protocol clinical trial (SPIRIT compliant)
title Effect of changes in serum levels of endogenous hydrogen sulfide on fracture healing: Study protocol clinical trial (SPIRIT compliant)
title_full Effect of changes in serum levels of endogenous hydrogen sulfide on fracture healing: Study protocol clinical trial (SPIRIT compliant)
title_fullStr Effect of changes in serum levels of endogenous hydrogen sulfide on fracture healing: Study protocol clinical trial (SPIRIT compliant)
title_full_unstemmed Effect of changes in serum levels of endogenous hydrogen sulfide on fracture healing: Study protocol clinical trial (SPIRIT compliant)
title_short Effect of changes in serum levels of endogenous hydrogen sulfide on fracture healing: Study protocol clinical trial (SPIRIT compliant)
title_sort effect of changes in serum levels of endogenous hydrogen sulfide on fracture healing: study protocol clinical trial (spirit compliant)
topic 6300
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7440181/
https://www.ncbi.nlm.nih.gov/pubmed/32243406
http://dx.doi.org/10.1097/MD.0000000000019684
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