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Prognostic role of galectins expression in patients with hepatic cancer: A meta-analysis
OBJECTIVE: The objective of this study was to illustrate the prognostic value of diversified galectins in patients with hepatic cancer via meta-analysis. METHODS: We conducted a systematic search on PubMed, Embase, The Cochrane Library, Web of Science, the Chinese National Knowledge Infrastructure (...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7440300/ https://www.ncbi.nlm.nih.gov/pubmed/32282710 http://dx.doi.org/10.1097/MD.0000000000019622 |
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author | Shao, Qi He, Jing Chen, Zhiming Wu, Changping |
author_facet | Shao, Qi He, Jing Chen, Zhiming Wu, Changping |
author_sort | Shao, Qi |
collection | PubMed |
description | OBJECTIVE: The objective of this study was to illustrate the prognostic value of diversified galectins in patients with hepatic cancer via meta-analysis. METHODS: We conducted a systematic search on PubMed, Embase, The Cochrane Library, Web of Science, the Chinese National Knowledge Infrastructure (CNKI) database, and Wanfang Data for studies that reported associations between galectin expression and the prognosis for hepatic cancer patients, from the inception of each database to March 20, 2019. The combined hazard ratio (HR) and 95% confidence interval (CI) were estimated to investigate the prognosis. RESULTS: We collected 11 studies of 1957 patients in our meta-analysis. The pooled results indicated that overall galectin expression was not correlated with OS (HR = 1.23, 95% CI = 0.84–1.79, P = .29) or DFS/RFS (HR = 0.808, 95% CI = 0.376–1.735, P = .42) in liver cancer patients. In stratified analyses, we observed that high galectin-1 and galectin-3 expression was significantly associated with poor OS. The pooled HR of galectin-4 and galectin-9 was correlated with improved OS. CONCLUSION: Our results indicate that the high expression of galectin-1 and -3 and the low expression of galectin-4 and -9 may be predictive prognostic factors for poor OS in liver cancer patients. |
format | Online Article Text |
id | pubmed-7440300 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-74403002020-09-04 Prognostic role of galectins expression in patients with hepatic cancer: A meta-analysis Shao, Qi He, Jing Chen, Zhiming Wu, Changping Medicine (Baltimore) 5700 OBJECTIVE: The objective of this study was to illustrate the prognostic value of diversified galectins in patients with hepatic cancer via meta-analysis. METHODS: We conducted a systematic search on PubMed, Embase, The Cochrane Library, Web of Science, the Chinese National Knowledge Infrastructure (CNKI) database, and Wanfang Data for studies that reported associations between galectin expression and the prognosis for hepatic cancer patients, from the inception of each database to March 20, 2019. The combined hazard ratio (HR) and 95% confidence interval (CI) were estimated to investigate the prognosis. RESULTS: We collected 11 studies of 1957 patients in our meta-analysis. The pooled results indicated that overall galectin expression was not correlated with OS (HR = 1.23, 95% CI = 0.84–1.79, P = .29) or DFS/RFS (HR = 0.808, 95% CI = 0.376–1.735, P = .42) in liver cancer patients. In stratified analyses, we observed that high galectin-1 and galectin-3 expression was significantly associated with poor OS. The pooled HR of galectin-4 and galectin-9 was correlated with improved OS. CONCLUSION: Our results indicate that the high expression of galectin-1 and -3 and the low expression of galectin-4 and -9 may be predictive prognostic factors for poor OS in liver cancer patients. Wolters Kluwer Health 2020-04-10 /pmc/articles/PMC7440300/ /pubmed/32282710 http://dx.doi.org/10.1097/MD.0000000000019622 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | 5700 Shao, Qi He, Jing Chen, Zhiming Wu, Changping Prognostic role of galectins expression in patients with hepatic cancer: A meta-analysis |
title | Prognostic role of galectins expression in patients with hepatic cancer: A meta-analysis |
title_full | Prognostic role of galectins expression in patients with hepatic cancer: A meta-analysis |
title_fullStr | Prognostic role of galectins expression in patients with hepatic cancer: A meta-analysis |
title_full_unstemmed | Prognostic role of galectins expression in patients with hepatic cancer: A meta-analysis |
title_short | Prognostic role of galectins expression in patients with hepatic cancer: A meta-analysis |
title_sort | prognostic role of galectins expression in patients with hepatic cancer: a meta-analysis |
topic | 5700 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7440300/ https://www.ncbi.nlm.nih.gov/pubmed/32282710 http://dx.doi.org/10.1097/MD.0000000000019622 |
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