Epigenomically Bistable Regions across Neuron-Specific Genes Govern Neuron Eligibility to a Coding Ensemble in the Hippocampus

Sensory inputs activate sparse neuronal ensembles in the dentate gyrus of the hippocampus, but how eligibility of individual neurons to recruitment is determined remains elusive. We identify thousands of largely bistable (CpG methylated or unmethylated) regions within neuronal gene bodies, establish...

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Detalles Bibliográficos
Autores principales: Odell, Shannon C., Taki, Faten, Klein, Shifra Liba, Chen, Rosa J., Levine, Olivia B., Skelly, Mary Jane, Nabila, Anika, Brindley, Elizabeth, Toth, Judit Gal, Dündar, Friederike, Sheridan, Caroline K., Fetcho, Robert N., Alonso, Alicia, Liston, Conor, Landau, Dan A., Pleil, Kristen E., Toth, Miklos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7440841/
https://www.ncbi.nlm.nih.gov/pubmed/32579919
http://dx.doi.org/10.1016/j.celrep.2020.107789

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