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Can sleep protect memories from catastrophic forgetting?
Continual learning remains an unsolved problem in artificial neural networks. The brain has evolved mechanisms to prevent catastrophic forgetting of old knowledge during new training. Building upon data suggesting the importance of sleep in learning and memory, we tested a hypothesis that sleep prot...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7440920/ https://www.ncbi.nlm.nih.gov/pubmed/32748786 http://dx.doi.org/10.7554/eLife.51005 |
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author | González, Oscar C Sokolov, Yury Krishnan, Giri P Delanois, Jean Erik Bazhenov, Maxim |
author_facet | González, Oscar C Sokolov, Yury Krishnan, Giri P Delanois, Jean Erik Bazhenov, Maxim |
author_sort | González, Oscar C |
collection | PubMed |
description | Continual learning remains an unsolved problem in artificial neural networks. The brain has evolved mechanisms to prevent catastrophic forgetting of old knowledge during new training. Building upon data suggesting the importance of sleep in learning and memory, we tested a hypothesis that sleep protects old memories from being forgotten after new learning. In the thalamocortical model, training a new memory interfered with previously learned old memories leading to degradation and forgetting of the old memory traces. Simulating sleep after new learning reversed the damage and enhanced old and new memories. We found that when a new memory competed for previously allocated neuronal/synaptic resources, sleep replay changed the synaptic footprint of the old memory to allow overlapping neuronal populations to store multiple memories. Our study predicts that memory storage is dynamic, and sleep enables continual learning by combining consolidation of new memory traces with reconsolidation of old memory traces to minimize interference. |
format | Online Article Text |
id | pubmed-7440920 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-74409202020-08-21 Can sleep protect memories from catastrophic forgetting? González, Oscar C Sokolov, Yury Krishnan, Giri P Delanois, Jean Erik Bazhenov, Maxim eLife Neuroscience Continual learning remains an unsolved problem in artificial neural networks. The brain has evolved mechanisms to prevent catastrophic forgetting of old knowledge during new training. Building upon data suggesting the importance of sleep in learning and memory, we tested a hypothesis that sleep protects old memories from being forgotten after new learning. In the thalamocortical model, training a new memory interfered with previously learned old memories leading to degradation and forgetting of the old memory traces. Simulating sleep after new learning reversed the damage and enhanced old and new memories. We found that when a new memory competed for previously allocated neuronal/synaptic resources, sleep replay changed the synaptic footprint of the old memory to allow overlapping neuronal populations to store multiple memories. Our study predicts that memory storage is dynamic, and sleep enables continual learning by combining consolidation of new memory traces with reconsolidation of old memory traces to minimize interference. eLife Sciences Publications, Ltd 2020-08-04 /pmc/articles/PMC7440920/ /pubmed/32748786 http://dx.doi.org/10.7554/eLife.51005 Text en © 2020, González et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience González, Oscar C Sokolov, Yury Krishnan, Giri P Delanois, Jean Erik Bazhenov, Maxim Can sleep protect memories from catastrophic forgetting? |
title | Can sleep protect memories from catastrophic forgetting? |
title_full | Can sleep protect memories from catastrophic forgetting? |
title_fullStr | Can sleep protect memories from catastrophic forgetting? |
title_full_unstemmed | Can sleep protect memories from catastrophic forgetting? |
title_short | Can sleep protect memories from catastrophic forgetting? |
title_sort | can sleep protect memories from catastrophic forgetting? |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7440920/ https://www.ncbi.nlm.nih.gov/pubmed/32748786 http://dx.doi.org/10.7554/eLife.51005 |
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