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Current approaches in laboratory testing for SARS-CoV-2
The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which began in Wuhan, Hubei Province, China, has rapidly spread to produce a global pandemic. It is now clear that person-to-person transmission of SARS-CoV-2 has been occurring and that the virus has been dramatically gro...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7441048/ https://www.ncbi.nlm.nih.gov/pubmed/32829053 http://dx.doi.org/10.1016/j.ijid.2020.08.041 |
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author | Xu, Yuzhong Cheng, Minggang Chen, Xinchun Zhu, Jialou |
author_facet | Xu, Yuzhong Cheng, Minggang Chen, Xinchun Zhu, Jialou |
author_sort | Xu, Yuzhong |
collection | PubMed |
description | The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which began in Wuhan, Hubei Province, China, has rapidly spread to produce a global pandemic. It is now clear that person-to-person transmission of SARS-CoV-2 has been occurring and that the virus has been dramatically growing in recent months. Early, rapid and accurate diagnosis is of great significance for curtailing the spread of SARS-CoV-2. There are currently several diagnostic techniques (e.g. viral culture and nucleic acid amplification test) being used to detect the virus. However, the sensitivity and specificity of these methods are quite different, with the sample source and detection limit varying greatly. This study reviewed all types and characteristics of the currently available laboratory diagnostic assays for detecting SARS-CoV-2 infection and summarized the selection strategies of testing and sampling sites at different disease stages to improve the diagnostic accuracy of Coronavirus Disease 2019 (COVID-19). |
format | Online Article Text |
id | pubmed-7441048 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74410482020-08-21 Current approaches in laboratory testing for SARS-CoV-2 Xu, Yuzhong Cheng, Minggang Chen, Xinchun Zhu, Jialou Int J Infect Dis Short Communication The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which began in Wuhan, Hubei Province, China, has rapidly spread to produce a global pandemic. It is now clear that person-to-person transmission of SARS-CoV-2 has been occurring and that the virus has been dramatically growing in recent months. Early, rapid and accurate diagnosis is of great significance for curtailing the spread of SARS-CoV-2. There are currently several diagnostic techniques (e.g. viral culture and nucleic acid amplification test) being used to detect the virus. However, the sensitivity and specificity of these methods are quite different, with the sample source and detection limit varying greatly. This study reviewed all types and characteristics of the currently available laboratory diagnostic assays for detecting SARS-CoV-2 infection and summarized the selection strategies of testing and sampling sites at different disease stages to improve the diagnostic accuracy of Coronavirus Disease 2019 (COVID-19). The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2020-11 2020-08-21 /pmc/articles/PMC7441048/ /pubmed/32829053 http://dx.doi.org/10.1016/j.ijid.2020.08.041 Text en © 2020 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Short Communication Xu, Yuzhong Cheng, Minggang Chen, Xinchun Zhu, Jialou Current approaches in laboratory testing for SARS-CoV-2 |
title | Current approaches in laboratory testing for SARS-CoV-2 |
title_full | Current approaches in laboratory testing for SARS-CoV-2 |
title_fullStr | Current approaches in laboratory testing for SARS-CoV-2 |
title_full_unstemmed | Current approaches in laboratory testing for SARS-CoV-2 |
title_short | Current approaches in laboratory testing for SARS-CoV-2 |
title_sort | current approaches in laboratory testing for sars-cov-2 |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7441048/ https://www.ncbi.nlm.nih.gov/pubmed/32829053 http://dx.doi.org/10.1016/j.ijid.2020.08.041 |
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