4-Phenylbutyrate ameliorates apoptotic neural cell death in Down syndrome by reducing protein aggregates

Individuals with Down syndrome (DS) commonly show unique pathological phenotypes throughout their life span. Besides the specific effects of dosage-sensitive genes on chromosome 21, recent studies have demonstrated that the gain of a chromosome exerts an adverse impact on cell physiology, regardless...

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Detalles Bibliográficos
Autores principales: Hirata, Katsuya, Nambara, Toshihiko, Kawatani, Keiji, Nawa, Nobutoshi, Yoshimatsu, Hidetaka, Kusakabe, Haruna, Banno, Kimihiko, Nishimura, Ken, Ohtaka, Manami, Nakanishi, Mahito, Taniguchi, Hidetoshi, Arahori, Hitomi, Wada, Kazuko, Ozono, Keiichi, Kitabatake, Yasuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7441064/
https://www.ncbi.nlm.nih.gov/pubmed/32820178
http://dx.doi.org/10.1038/s41598-020-70362-x

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