Role of the DEK oncogene in the development of squamous cell carcinoma

DEK is a highly conserved nuclear factor that plays an important role in the regulation of multiple cellular processes. DEK was discovered to be an oncogene as a fusion with NUP214 gene, which results in producing DEK-NUP214 proteins, in a subset of patients with acute myeloid leukemia. Subsequently...

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Autores principales: Ishida, Kazuhisa, Nakashima, Takayuki, Shibata, Toshiyuki, Hara, Akira, Tomita, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7441080/
https://www.ncbi.nlm.nih.gov/pubmed/32656741
http://dx.doi.org/10.1007/s10147-020-01735-5
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author Ishida, Kazuhisa
Nakashima, Takayuki
Shibata, Toshiyuki
Hara, Akira
Tomita, Hiroyuki
author_facet Ishida, Kazuhisa
Nakashima, Takayuki
Shibata, Toshiyuki
Hara, Akira
Tomita, Hiroyuki
author_sort Ishida, Kazuhisa
collection PubMed
description DEK is a highly conserved nuclear factor that plays an important role in the regulation of multiple cellular processes. DEK was discovered to be an oncogene as a fusion with NUP214 gene, which results in producing DEK-NUP214 proteins, in a subset of patients with acute myeloid leukemia. Subsequently, DEK overexpression was reported in many cancers, thus DEK itself is considered to be an oncoprotein. DEK has been reported to play important roles in the progression of early and late stage squamous cell carcinoma (SCC) and is useful for early diagnosis of the disease. These findings have made DEK an attractive therapeutic target, especially for human papillomavirus (HPV)-associated SCC. However, the mechanism of DEK in SCC remains unclear. In this review, we discuss human DEK oncogene-related SCC.
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spelling pubmed-74410802020-08-27 Role of the DEK oncogene in the development of squamous cell carcinoma Ishida, Kazuhisa Nakashima, Takayuki Shibata, Toshiyuki Hara, Akira Tomita, Hiroyuki Int J Clin Oncol Review Article DEK is a highly conserved nuclear factor that plays an important role in the regulation of multiple cellular processes. DEK was discovered to be an oncogene as a fusion with NUP214 gene, which results in producing DEK-NUP214 proteins, in a subset of patients with acute myeloid leukemia. Subsequently, DEK overexpression was reported in many cancers, thus DEK itself is considered to be an oncoprotein. DEK has been reported to play important roles in the progression of early and late stage squamous cell carcinoma (SCC) and is useful for early diagnosis of the disease. These findings have made DEK an attractive therapeutic target, especially for human papillomavirus (HPV)-associated SCC. However, the mechanism of DEK in SCC remains unclear. In this review, we discuss human DEK oncogene-related SCC. Springer Singapore 2020-07-12 2020 /pmc/articles/PMC7441080/ /pubmed/32656741 http://dx.doi.org/10.1007/s10147-020-01735-5 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Ishida, Kazuhisa
Nakashima, Takayuki
Shibata, Toshiyuki
Hara, Akira
Tomita, Hiroyuki
Role of the DEK oncogene in the development of squamous cell carcinoma
title Role of the DEK oncogene in the development of squamous cell carcinoma
title_full Role of the DEK oncogene in the development of squamous cell carcinoma
title_fullStr Role of the DEK oncogene in the development of squamous cell carcinoma
title_full_unstemmed Role of the DEK oncogene in the development of squamous cell carcinoma
title_short Role of the DEK oncogene in the development of squamous cell carcinoma
title_sort role of the dek oncogene in the development of squamous cell carcinoma
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7441080/
https://www.ncbi.nlm.nih.gov/pubmed/32656741
http://dx.doi.org/10.1007/s10147-020-01735-5
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