Cargando…

The anesthetic bupivacaine induces cardiotoxicity by targeting L-type voltage-dependent calcium channels

OBJECTIVE: Bupivacaine is an amide local anesthetic with possible side effects that include an irregular heart rate. However, the mechanism of bupivacaine-induced cardiotoxicity has not been fully elucidated, thus we aimed to examine this mechanism. METHODS: We performed electrocardiogram recordings...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gao, YaNan, Chen, Bo, Zhang, Xue, Yang, Rui, Hua, QingLi, Li, BaiDong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2020
Materias:	Pre-Clinical Research Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7441289/ https://www.ncbi.nlm.nih.gov/pubmed/32812463 http://dx.doi.org/10.1177/0300060520942619

Ejemplares similares

Voltage- and Calcium-Dependent Inactivation of Calcium Channels in Lymnaea Neurons
por: Gera, Shalini, et al.
Publicado: (1999)

Insulin effect on bupivacaine-induced cardiotoxicity in rabbits
por: Choi, Yun Suk, et al.
Publicado: (2011)

Molecular mechanism of allosteric modification of voltage-dependent sodium channels by local anesthetics
por: Arcisio-Miranda, Manoel, et al.
Publicado: (2010)

Bio-Inspired Voltage-Dependent Calcium Channel Blockers
por: Yang, Tingting, et al.
Publicado: (2013)

Melatonin attenuates AFB1-induced cardiotoxicity via the NLRP3 signalling pathway
por: Yan, Hui, et al.
Publicado: (2020)

Antioxidant effect of acetyl-l-carnitine against cisplatin-induced cardiotoxicity
por: Bayrak, Serdar, et al.
Publicado: (2020)

The effects of levosimendan and dobutamine in experimental bupivacaine-induced cardiotoxicity
por: Kandemir, Ulku, et al.
Publicado: (2013)

Chondrotoxicity of Local Anesthetics: Liposomal Bupivacaine Is Less Chondrotoxic than Standard Bupivacaine
por: Farmer, Travis, et al.
Publicado: (2020)

ANESTHETIC AND CALCIUM ACTION IN THE VOLTAGE CLAMPED SQUID GIANT AXON
por: Shanes, A. M., et al.
Publicado: (1959)

The effects of an insulin-glucose-potassium (IGK) pretreatment on the bupivacaine cardiotoxicity
por: Kim, Jin-Tae, et al.
Publicado: (2013)

Comparison of Local Anesthetic Effect of Bupivacaine versus Bupivacaine plus Dexamethasone in Nasal Surgery
por: Ma’somi, Abdolhosein, et al.
Publicado: (2013)

Voltage-Dependent Calcium Channels, Calcium Binding Proteins, and Their Interaction in the Pathological Process of Epilepsy
por: Xu, Jie-Hua, et al.
Publicado: (2018)

Anesthetic management of precise radiotherapy under apnea-like condition
por: Zhang, Shilong, et al.
Publicado: (2021)

Elevations of intracellular calcium reflect normal voltage-dependent behavior, and not constitutive activity, of voltage-dependent calcium channels in gastrointestinal and vascular smooth muscle
por: McCarron, John G., et al.
Publicado: (2009)

Engineering selectivity into RGK GTPase inhibition of voltage-dependent calcium channels
por: Puckerin, Akil A., et al.
Publicado: (2018)

Voltage Dependent N Type Calcium Channel in Mouse Egg Fertilization
por: Eum, Jin Hee, et al.
Publicado: (2020)

Yangxin granules alleviate doxorubicin-induced cardiotoxicity by suppressing oxidative stress and apoptosis mediated by AKT/GSK3β/β-catenin signaling
por: Ren, Dezhi, et al.
Publicado: (2020)

Optogenetic Control of Voltage‐Gated Calcium Channels
por: Ma, Guolin, et al.
Publicado: (2018)

Hypocapnia delays subsequent bupivacaine cardiotoxicity in rats under sevoflurane anesthesia
por: Yu, Shuchun, et al.
Publicado: (2014)

Effects of delta-opioid receptor agonist pretreatment on the cardiotoxicity of bupivacaine in rats
por: Wang, Chenran, et al.
Publicado: (2022)

Intralipid fails to rescue bupivacaine-induced cardiotoxicity in late-pregnant rats
por: Sherman, Caitlin, et al.
Publicado: (2022)

Gallic Acid Inhibits Mesaconitine-Activated TRPV1-Channel-Induced Cardiotoxicity
por: Han, Shu, et al.
Publicado: (2022)

Large-Conductance Calcium-Activated Potassium Channels and Voltage-Dependent Sodium Channels in Human Cementoblasts
por: Kamata, Satomi, et al.
Publicado: (2021)

Voltage-dependent inactivation of T-tubular skeletal calcium channels in planar lipid bilayers
Publicado: (1991)

Intraluminal pressure elevates intracellular calcium and contracts CNS pericytes: Role of voltage-dependent calcium channels
por: Klug, Nicholas R., et al.
Publicado: (2023)

The active-zone protein Munc13 controls the use-dependence of presynaptic voltage-gated calcium channels
por: Calloway, Nathaniel, et al.
Publicado: (2015)

Functions of Presynaptic Voltage-gated Calcium Channels
por: Dolphin, Annette C
Publicado: (2020)

RGK regulation of voltage-gated calcium channels
por: Zafir, BURAEI, et al.
Publicado: (2015)

Microtubule-Mediated Misregulation of Junctophilin-2 Underlies T-Tubule Disruptions and Calcium Mishandling in mdx Mice
por: Prins, Kurt W., et al.
Publicado: (2016)

Simultaneous Two-Photon Voltage or Calcium Imaging and Multi-Channel Local Field Potential Recordings in Barrel Cortex of Awake and Anesthetized Mice
por: Cecchetto, Claudia, et al.
Publicado: (2021)

The anti-alcohol dependency drug disulfiram inhibits the viability and progression of gastric cancer cells by regulating the Wnt and NF-κB pathways
por: Zhang, Jun, et al.
Publicado: (2020)

Voltage-dependent inactivation of slow calcium channels in intact twitch muscle fibers of the frog
Publicado: (1989)

Aminoglycoside antibiotics block voltage-dependent calcium channels in intact vertebrate nerve terminals
Publicado: (1992)

A Dihydropyridine-sensitive Voltage-dependent Calcium Channel in the Sarcolemmal Membrane of Crustacean Muscle
por: Erxleben, Christian, et al.
Publicado: (1997)

Subconductance States of a Mutant NMDA Receptor Channel Kinetics, Calcium, and Voltage Dependence
por: Premkumar, Louis S., et al.
Publicado: (1997)

Determinants of the voltage dependence of G protein modulation within calcium channel β subunits
por: Dresviannikov, Andriy V., et al.
Publicado: (2008)

Selective pressure modulation of synaptic voltage‐dependent calcium channels—involvement in HPNS mechanism
por: Aviner, Ben, et al.
Publicado: (2016)

Lavender Oil-Potent Anxiolytic Properties via Modulating Voltage Dependent Calcium Channels
por: Schuwald, Anita M., et al.
Publicado: (2013)

Designer genetically encoded voltage‐dependent calcium channel inhibitors inspired by RGK GTPases
por: Colecraft, Henry M.
Publicado: (2020)

Resveratrol attenuates cortical neuron activity: roles of large conductance calcium-activated potassium channels and voltage-gated sodium channels
por: Wang, Ya-Jean, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_k8e0u9lbqj2ai3ikrlsh4s18m4