Cargando…

BRCA1 and BRCA2 pathogenic variant carriers and endometrial cancer risk: A cohort study

BACKGROUND: An association between BRCA pathogenic variants and an increased endometrial cancer risk, specifically serous-like endometrial cancer, has been postulated but remains unproven, particularly for BRCA2 carriers. Mechanistic evidence is lacking, and any link may be related to tamoxifen expo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kitson, Sarah J., Bafligil, Cemsel, Ryan, Neil A.J., Lalloo, Fiona, Woodward, Emma R., Clayton, Richard D., Edmondson, Richard J., Bolton, James, Crosbie, Emma J., Evans, D. Gareth
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Science Ltd 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7441309/ https://www.ncbi.nlm.nih.gov/pubmed/32698099 http://dx.doi.org/10.1016/j.ejca.2020.05.030

Ejemplares similares

Specialist oncological surgery for removal of the ovaries and fallopian tubes in BRCA1 and BRCA2 pathogenic variant carriers may reduce primary peritoneal cancer risk to very low levels
por: Crosbie, Emma J., et al.
Publicado: (2020)

Parity and breast cancer risk among BRCA1 and BRCA2 mutation carriers
por: Antoniou, Antonis C, et al.
Publicado: (2006)

MSH2 is the very young onset ovarian cancer predisposition gene, not BRCA1
por: Flaum, Nicola, et al.
Publicado: (2023)

Association between genetic polymorphisms and endometrial cancer risk: a systematic review
por: Bafligil, Cemsel, et al.
Publicado: (2020)

BRCA and lynch syndrome-associated ovarian cancers behave differently
por: Ryan, Neil A.J., et al.
Publicado: (2017)

Child and adult adiposity and subtype-specific endometrial cancer risk: a multivariable Mendelian randomisation study
por: Kennedy, Oliver J., et al.
Publicado: (2022)

Penetrance estimates for BRCA1 and BRCA2 based on genetic testing in a Clinical Cancer Genetics service setting: Risks of breast/ovarian cancer quoted should reflect the cancer burden in the family
por: Evans, D Gareth, et al.
Publicado: (2008)

Risks of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers
por: Ahmed, M, et al.
Publicado: (2010)

Young age at first pregnancy does protect against early onset breast cancer in BRCA1 and BRCA2 mutation carriers
por: Evans, DG, et al.
Publicado: (2017)

Is Reflex Germline BRCA1/2 Testing Necessary in Women Diagnosed with Non-Mucinous High-Grade Epithelial Ovarian Cancer Aged 80 Years or Older?
por: Morgan, Robert D., et al.
Publicado: (2023)

Can multiple SNP testing in BRCA2 and BRCA1 female carriers be used to improve risk prediction models in conjunction with clinical assessment?
por: Prosperi, Mattia CF, et al.
Publicado: (2014)

Risk of Contralateral Breast Cancer in Women with and without Pathogenic Variants in BRCA1, BRCA2, and TP53 Genes in Women with Very Early-Onset (<36 Years) Breast Cancer
por: Hyder, Zerin, et al.
Publicado: (2020)

Advances in genetic technologies result in improved diagnosis of mismatch repair deficiency in colorectal and endometrial cancers
por: Evans, D Gareth, et al.
Publicado: (2022)

The unrecognized burden of cardiovascular risk factors in women newly diagnosed with endometrial cancer: A prospective case control study
por: Kitson, Sarah J., et al.
Publicado: (2018)

Longer term effects of the Angelina Jolie effect: increased risk-reducing mastectomy rates in BRCA carriers and other high-risk women
por: Evans, D. Gareth, et al.
Publicado: (2015)

BRCA locus-specific loss of heterozygosity in germline BRCA1 and BRCA2 carriers
por: Maxwell, Kara N., et al.
Publicado: (2017)

The incidence of pancreatic cancer in BRCA1 and BRCA2 mutation carriers
por: Iqbal, J, et al.
Publicado: (2012)

Gene Panel Testing for Breast Cancer Reveals Differential Effect of Prior BRCA1/2 Probability
por: Evans, D. Gareth, et al.
Publicado: (2021)

Associations of height, body mass index, and weight gain with breast cancer risk in carriers of a pathogenic variant in BRCA1 or BRCA2: the BRCA1 and BRCA2 Cohort Consortium
por: Kast, Karin, et al.
Publicado: (2023)

Should unaffected female BRCA2 pathogenic variant carriers be told there is little or no advantage from risk reducing mastectomy?
por: Evans, D. Gareth, et al.
Publicado: (2019)

Multi-trait genome-wide association study identifies a novel endometrial cancer risk locus that associates with testosterone levels
por: Wang, Xuemin, et al.
Publicado: (2023)

Clinical Considerations of BRCA1- and BRCA2-Mutation Carriers: A Review
por: Bougie, O., et al.
Publicado: (2011)

Predictors of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers
por: Metcalfe, K, et al.
Publicado: (2011)

Prostate screening uptake in Australian BRCA1 and BRCA2 carriers
por: McKinley, Joanne M, et al.
Publicado: (2007)

The avoiding late diagnosis of ovarian cancer (ALDO) project; a pilot national surveillance programme for women with pathogenic germline variants in BRCA1 and BRCA2
por: Philpott, Sue, et al.
Publicado: (2023)

Are BRCA1- and BRCA2-related breast cancers associated with increased mortality?
por: Gareth Evans, D, et al.
Publicado: (2004)

Preferences for breast cancer risk reduction among BRCA1/BRCA2 mutation carriers: a discrete-choice experiment
por: Liede, Alexander, et al.
Publicado: (2017)

Copy number variants as modifiers of breast cancer risk for BRCA1/BRCA2 pathogenic variant carriers
por: Hakkaart, Christopher, et al.
Publicado: (2022)

Breast tumor characteristics of BRCA1 and BRCA2 gene mutation carriers on MRI
por: Veltman, J., et al.
Publicado: (2008)

Fanconi Anaemia, Childhood Cancer and the BRCA Genes
por: Woodward, Emma R., et al.
Publicado: (2021)

Effects of BRCA2 cis-regulation in normal breast and cancer risk amongst BRCA2 mutation carriers
por: Maia, Ana-Teresa, et al.
Publicado: (2012)

Association of Mismatch Repair Mutation With Age at Cancer Onset in Lynch Syndrome: Implications for Stratified Surveillance Strategies
por: Ryan, Neil A. J., et al.
Publicado: (2017)

Selenium and the risk of cancer in BRCA1 carriers
por: Lubinski, J, et al.
Publicado: (2011)

Cancer risks among BRCA1 and BRCA2 mutation carriers
por: Levy-Lahad, E, et al.
Publicado: (2007)

Screening BRCA1 and BRCA2 Mutation Carriers for Breast Cancer
por: Warner, Ellen
Publicado: (2018)

Gastric Cancer Risk and Pathogenesis in BRCA1 and BRCA2 Carriers
por: Buckley, Kole H., et al.
Publicado: (2022)

Evaluation of the XRCC1 gene as a phenotypic modifier in BRCA1/2 mutation carriers. Results from the consortium of investigators of modifiers of BRCA1/BRCA2
por: Osorio, A, et al.
Publicado: (2011)

Breastfeeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers
por: Kotsopoulos, Joanne, et al.
Publicado: (2012)

An international initiative to identify genetic modifiers of cancer risk in BRCA1 and BRCA2 mutation carriers: the Consortium of Investigators of Modifiers of BRCA1 and BRCA2 (CIMBA)
por: Chenevix-Trench, Georgia, et al.
Publicado: (2007)

Multifocal breast cancers are more prevalent in BRCA2 versus BRCA1 mutation carriers
por: McCrorie, Alan D, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_07ocgju0kvour55rtvr4m4up33