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Dysregulated hepcidin response to dietary iron in male mice with reduced Gnpat expression

Exome sequencing has identified the glyceronephosphate O-acyltransferase (GNPAT) gene as a genetic modifier of iron overload in hereditary hemochromatosis (HH). Subjects with HFE (Homeostatic Iron Regulator) p.C282Y mutations and the GNPAT p.D519G variant had more iron loading compared with subjects...

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Detalles Bibliográficos
Autores principales:	Rishi, Gautam, Secondes, Eriza S., Asplett, Kiran, Wallace, Daniel F., Ostini, Lesa, Berger, Johannes, Subramaniam, V. Nathan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2020
Materias:	Gastrointestinal, Renal & Hepatic Systems
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7441371/ https://www.ncbi.nlm.nih.gov/pubmed/32766721 http://dx.doi.org/10.1042/BSR20201508

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