The Role and Regulation of Pulmonary Artery Smooth Muscle Cells in Pulmonary Hypertension

Pulmonary hypertension (PH) is one of the most devastating cardiovascular diseases worldwide and it draws much attention from numerous scientists. As an indispensable part of pulmonary artery, smooth muscle cells are worthy of being carefully investigated. To elucidate the pathogenesis of PH, severa...

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Detalles Bibliográficos
Autores principales: He, Shixin, Zhu, Tengteng, Fang, Zhenfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7441461/
https://www.ncbi.nlm.nih.gov/pubmed/32850144
http://dx.doi.org/10.1155/2020/1478291
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author He, Shixin
Zhu, Tengteng
Fang, Zhenfei
author_facet He, Shixin
Zhu, Tengteng
Fang, Zhenfei
author_sort He, Shixin
collection PubMed
description Pulmonary hypertension (PH) is one of the most devastating cardiovascular diseases worldwide and it draws much attention from numerous scientists. As an indispensable part of pulmonary artery, smooth muscle cells are worthy of being carefully investigated. To elucidate the pathogenesis of PH, several theories focusing on pulmonary artery smooth muscle cells (PASMC), such as hyperproliferation, resistance to apoptosis, and cancer theory, have been proposed and widely studied. Here, we tried to summarize the studies, concentrating on the role of PASMC in the development of PH, feasible molecular basis to intervene, and potential treatment to PH.
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spelling pubmed-74414612020-08-25 The Role and Regulation of Pulmonary Artery Smooth Muscle Cells in Pulmonary Hypertension He, Shixin Zhu, Tengteng Fang, Zhenfei Int J Hypertens Review Article Pulmonary hypertension (PH) is one of the most devastating cardiovascular diseases worldwide and it draws much attention from numerous scientists. As an indispensable part of pulmonary artery, smooth muscle cells are worthy of being carefully investigated. To elucidate the pathogenesis of PH, several theories focusing on pulmonary artery smooth muscle cells (PASMC), such as hyperproliferation, resistance to apoptosis, and cancer theory, have been proposed and widely studied. Here, we tried to summarize the studies, concentrating on the role of PASMC in the development of PH, feasible molecular basis to intervene, and potential treatment to PH. Hindawi 2020-08-11 /pmc/articles/PMC7441461/ /pubmed/32850144 http://dx.doi.org/10.1155/2020/1478291 Text en Copyright © 2020 Shixin He et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
He, Shixin
Zhu, Tengteng
Fang, Zhenfei
The Role and Regulation of Pulmonary Artery Smooth Muscle Cells in Pulmonary Hypertension
title The Role and Regulation of Pulmonary Artery Smooth Muscle Cells in Pulmonary Hypertension
title_full The Role and Regulation of Pulmonary Artery Smooth Muscle Cells in Pulmonary Hypertension
title_fullStr The Role and Regulation of Pulmonary Artery Smooth Muscle Cells in Pulmonary Hypertension
title_full_unstemmed The Role and Regulation of Pulmonary Artery Smooth Muscle Cells in Pulmonary Hypertension
title_short The Role and Regulation of Pulmonary Artery Smooth Muscle Cells in Pulmonary Hypertension
title_sort role and regulation of pulmonary artery smooth muscle cells in pulmonary hypertension
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7441461/
https://www.ncbi.nlm.nih.gov/pubmed/32850144
http://dx.doi.org/10.1155/2020/1478291
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