Atherogenic L5 LDL induces cardiomyocyte apoptosis and inhibits K(ATP) channels through CaMKII activation

BACKGROUND: Cardiac Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) activation plays a critical role in cardiomyocyte (CM) apoptosis and arrhythmia. Functional ATP-sensitive potassium (K(ATP)) channels are essential for cardiac protection during ischemia. In cultured CMs, L5 low-density lipop...

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Detalles Bibliográficos
Autores principales: Ma, Yanzhuo, Cheng, Nancy, Sun, Junping, Lu, Jonathan Xuhai, Abbasi, Shahrzad, Wu, Geru, Lee, An-Sheng, Sawamura, Tatsuya, Cheng, Jie, Chen, Chu-Huang, Xi, Yutao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7441649/
https://www.ncbi.nlm.nih.gov/pubmed/32825832
http://dx.doi.org/10.1186/s12944-020-01368-7

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