Cargando…

The impact of high-intensity interval training exercise on breast cancer survivors: a pilot study to explore fitness, cardiac regulation and biomarkers of the stress systems

BACKGROUND: Cardiovascular disease (CVD) remains the largest cause of death in breast cancer survivors. The aim of this study was to explore the impact of exercise intensity on aerobic fitness and autonomic cardiac regulation (heart rate variability (HRV)) and salivary biomarkers of the stress syste...

Descripción completa

Detalles Bibliográficos
Autores principales: Toohey, Kellie, Pumpa, Kate, McKune, Andrew, Cooke, Julie, Welvaert, Marijke, Northey, Joseph, Quinlan, Clare, Semple, Stuart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7441660/
https://www.ncbi.nlm.nih.gov/pubmed/32819304
http://dx.doi.org/10.1186/s12885-020-07295-1
_version_ 1783573335573004288
author Toohey, Kellie
Pumpa, Kate
McKune, Andrew
Cooke, Julie
Welvaert, Marijke
Northey, Joseph
Quinlan, Clare
Semple, Stuart
author_facet Toohey, Kellie
Pumpa, Kate
McKune, Andrew
Cooke, Julie
Welvaert, Marijke
Northey, Joseph
Quinlan, Clare
Semple, Stuart
author_sort Toohey, Kellie
collection PubMed
description BACKGROUND: Cardiovascular disease (CVD) remains the largest cause of death in breast cancer survivors. The aim of this study was to explore the impact of exercise intensity on aerobic fitness and autonomic cardiac regulation (heart rate variability (HRV)) and salivary biomarkers of the stress systems (HPA-axis, cortisol; sympathetic nervous system, α-amylase) and mucosal immunity (secretory(s)-IgA), markers of increased risk of CVD in breast cancer survivors. METHODS: Participants were randomly assigned to; 1) high intensity interval training (HIIT); 2) moderate-intensity, continuous aerobic training (CMIT); or 3) a wait-list control (CON) for a 12-week (36 session) stationary cycling intervention. Cardiorespiratory fitness (VO(2peak)), resting HRV and salivary biomarkers were measured at baseline 2–4 d pre-intervention and 2–4 d post the last exercise session. RESULTS: Seventeen participants were included in this study (62 ± 8 years, HIIT; n = 6, CMIT; n = 5, CON; n = 6). A significant improvement (p ≤ 0.05) was observed for VO(2peak) in the HIIT group; 19.3% (B = 3.98, 95%CI = [1.89; 4.02]) and a non-significant increase in the CMIT group; 5.6% (B = 1.96, 95%CI = [− 0.11; 4.03]), compared with a 2.6% (B = − 0.64, 95%CI = [− 2.10; 0.82]) decrease in the CON group. Post intervention improvements in HRV markers of vagal activity (log (ln)LF/HF, LnRMSSD) and sympathetic nervous system (α-amylase waking response) occurred for individuals exhibiting outlying (> 95% CI) levels at baseline compared to general population. CONCLUSION: High intensity interval training improved cardiovascular fitness in breast cancer survivors and improved cardiac regulation, and sympathetic nervous system (stress) responses in some individuals. High-intensity interval training was safe and effective for breast cancer survivors to participate in with promising results as a time efficient intensity to improve physical health and stress, reducing CVD risk. TRIAL REGISTRATION: This pilot study was retrospectively registered through the Australian New Zealand Clinical Trials Registry (ANZCTR): ACTRN12620000684921.
format Online
Article
Text
id pubmed-7441660
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-74416602020-08-24 The impact of high-intensity interval training exercise on breast cancer survivors: a pilot study to explore fitness, cardiac regulation and biomarkers of the stress systems Toohey, Kellie Pumpa, Kate McKune, Andrew Cooke, Julie Welvaert, Marijke Northey, Joseph Quinlan, Clare Semple, Stuart BMC Cancer Research Article BACKGROUND: Cardiovascular disease (CVD) remains the largest cause of death in breast cancer survivors. The aim of this study was to explore the impact of exercise intensity on aerobic fitness and autonomic cardiac regulation (heart rate variability (HRV)) and salivary biomarkers of the stress systems (HPA-axis, cortisol; sympathetic nervous system, α-amylase) and mucosal immunity (secretory(s)-IgA), markers of increased risk of CVD in breast cancer survivors. METHODS: Participants were randomly assigned to; 1) high intensity interval training (HIIT); 2) moderate-intensity, continuous aerobic training (CMIT); or 3) a wait-list control (CON) for a 12-week (36 session) stationary cycling intervention. Cardiorespiratory fitness (VO(2peak)), resting HRV and salivary biomarkers were measured at baseline 2–4 d pre-intervention and 2–4 d post the last exercise session. RESULTS: Seventeen participants were included in this study (62 ± 8 years, HIIT; n = 6, CMIT; n = 5, CON; n = 6). A significant improvement (p ≤ 0.05) was observed for VO(2peak) in the HIIT group; 19.3% (B = 3.98, 95%CI = [1.89; 4.02]) and a non-significant increase in the CMIT group; 5.6% (B = 1.96, 95%CI = [− 0.11; 4.03]), compared with a 2.6% (B = − 0.64, 95%CI = [− 2.10; 0.82]) decrease in the CON group. Post intervention improvements in HRV markers of vagal activity (log (ln)LF/HF, LnRMSSD) and sympathetic nervous system (α-amylase waking response) occurred for individuals exhibiting outlying (> 95% CI) levels at baseline compared to general population. CONCLUSION: High intensity interval training improved cardiovascular fitness in breast cancer survivors and improved cardiac regulation, and sympathetic nervous system (stress) responses in some individuals. High-intensity interval training was safe and effective for breast cancer survivors to participate in with promising results as a time efficient intensity to improve physical health and stress, reducing CVD risk. TRIAL REGISTRATION: This pilot study was retrospectively registered through the Australian New Zealand Clinical Trials Registry (ANZCTR): ACTRN12620000684921. BioMed Central 2020-08-20 /pmc/articles/PMC7441660/ /pubmed/32819304 http://dx.doi.org/10.1186/s12885-020-07295-1 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Toohey, Kellie
Pumpa, Kate
McKune, Andrew
Cooke, Julie
Welvaert, Marijke
Northey, Joseph
Quinlan, Clare
Semple, Stuart
The impact of high-intensity interval training exercise on breast cancer survivors: a pilot study to explore fitness, cardiac regulation and biomarkers of the stress systems
title The impact of high-intensity interval training exercise on breast cancer survivors: a pilot study to explore fitness, cardiac regulation and biomarkers of the stress systems
title_full The impact of high-intensity interval training exercise on breast cancer survivors: a pilot study to explore fitness, cardiac regulation and biomarkers of the stress systems
title_fullStr The impact of high-intensity interval training exercise on breast cancer survivors: a pilot study to explore fitness, cardiac regulation and biomarkers of the stress systems
title_full_unstemmed The impact of high-intensity interval training exercise on breast cancer survivors: a pilot study to explore fitness, cardiac regulation and biomarkers of the stress systems
title_short The impact of high-intensity interval training exercise on breast cancer survivors: a pilot study to explore fitness, cardiac regulation and biomarkers of the stress systems
title_sort impact of high-intensity interval training exercise on breast cancer survivors: a pilot study to explore fitness, cardiac regulation and biomarkers of the stress systems
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7441660/
https://www.ncbi.nlm.nih.gov/pubmed/32819304
http://dx.doi.org/10.1186/s12885-020-07295-1
work_keys_str_mv AT tooheykellie theimpactofhighintensityintervaltrainingexerciseonbreastcancersurvivorsapilotstudytoexplorefitnesscardiacregulationandbiomarkersofthestresssystems
AT pumpakate theimpactofhighintensityintervaltrainingexerciseonbreastcancersurvivorsapilotstudytoexplorefitnesscardiacregulationandbiomarkersofthestresssystems
AT mckuneandrew theimpactofhighintensityintervaltrainingexerciseonbreastcancersurvivorsapilotstudytoexplorefitnesscardiacregulationandbiomarkersofthestresssystems
AT cookejulie theimpactofhighintensityintervaltrainingexerciseonbreastcancersurvivorsapilotstudytoexplorefitnesscardiacregulationandbiomarkersofthestresssystems
AT welvaertmarijke theimpactofhighintensityintervaltrainingexerciseonbreastcancersurvivorsapilotstudytoexplorefitnesscardiacregulationandbiomarkersofthestresssystems
AT northeyjoseph theimpactofhighintensityintervaltrainingexerciseonbreastcancersurvivorsapilotstudytoexplorefitnesscardiacregulationandbiomarkersofthestresssystems
AT quinlanclare theimpactofhighintensityintervaltrainingexerciseonbreastcancersurvivorsapilotstudytoexplorefitnesscardiacregulationandbiomarkersofthestresssystems
AT semplestuart theimpactofhighintensityintervaltrainingexerciseonbreastcancersurvivorsapilotstudytoexplorefitnesscardiacregulationandbiomarkersofthestresssystems
AT tooheykellie impactofhighintensityintervaltrainingexerciseonbreastcancersurvivorsapilotstudytoexplorefitnesscardiacregulationandbiomarkersofthestresssystems
AT pumpakate impactofhighintensityintervaltrainingexerciseonbreastcancersurvivorsapilotstudytoexplorefitnesscardiacregulationandbiomarkersofthestresssystems
AT mckuneandrew impactofhighintensityintervaltrainingexerciseonbreastcancersurvivorsapilotstudytoexplorefitnesscardiacregulationandbiomarkersofthestresssystems
AT cookejulie impactofhighintensityintervaltrainingexerciseonbreastcancersurvivorsapilotstudytoexplorefitnesscardiacregulationandbiomarkersofthestresssystems
AT welvaertmarijke impactofhighintensityintervaltrainingexerciseonbreastcancersurvivorsapilotstudytoexplorefitnesscardiacregulationandbiomarkersofthestresssystems
AT northeyjoseph impactofhighintensityintervaltrainingexerciseonbreastcancersurvivorsapilotstudytoexplorefitnesscardiacregulationandbiomarkersofthestresssystems
AT quinlanclare impactofhighintensityintervaltrainingexerciseonbreastcancersurvivorsapilotstudytoexplorefitnesscardiacregulationandbiomarkersofthestresssystems
AT semplestuart impactofhighintensityintervaltrainingexerciseonbreastcancersurvivorsapilotstudytoexplorefitnesscardiacregulationandbiomarkersofthestresssystems