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Current Status of Research on the Role of Circular RNAs in Hepatocellular Carcinoma and Clinical Implications

The latest statistics show that rates of morbidity and mortality for hepatocellular carcinoma are gradually increasing over time. Accumulating evidence indicates that circular RNAs (circRNAs) participate in the regulation of gene transcription and translation and exert a crucial role in endogenous R...

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Autores principales: Zou, Ren-Chao, Li, Ling-Lin, Yuan, Hong-Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7441742/
https://www.ncbi.nlm.nih.gov/pubmed/32779638
http://dx.doi.org/10.12659/MSM.923832
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author Zou, Ren-Chao
Li, Ling-Lin
Yuan, Hong-Ling
author_facet Zou, Ren-Chao
Li, Ling-Lin
Yuan, Hong-Ling
author_sort Zou, Ren-Chao
collection PubMed
description The latest statistics show that rates of morbidity and mortality for hepatocellular carcinoma are gradually increasing over time. Accumulating evidence indicates that circular RNAs (circRNAs) participate in the regulation of gene transcription and translation and exert a crucial role in endogenous RNA network. circRNAs are implicated in the pathogenesis of numerous tumors including hepatocellular carcinoma (HCC), gastric carcinoma and bladder cancer. Of note, the effect of circRNAs in HCC has drawn increasing public attention. Previous studies revealed that the function of circRNAs mainly consists of sponges of miRNA and RNA-binding proteins, alternative splicing of pre-mRNAs, transcriptional and translational regulators, and potential to encode proteins. In addition, recent research data indicate that the expression level of circRNAs is closely correlated with metastasis, invasion, and occurrence of HCC in patients. These findings imply that circRNAs may be useful as biomarkers for diagnosis and prediction of prognosis of HCC. In this review, we have systemically summarized current viewpoints regarding the role of circRNAs expression in HCC to provide an important reference illustrating the underlying mechanism of HCC.
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spelling pubmed-74417422020-08-28 Current Status of Research on the Role of Circular RNAs in Hepatocellular Carcinoma and Clinical Implications Zou, Ren-Chao Li, Ling-Lin Yuan, Hong-Ling Med Sci Monit Review Articles The latest statistics show that rates of morbidity and mortality for hepatocellular carcinoma are gradually increasing over time. Accumulating evidence indicates that circular RNAs (circRNAs) participate in the regulation of gene transcription and translation and exert a crucial role in endogenous RNA network. circRNAs are implicated in the pathogenesis of numerous tumors including hepatocellular carcinoma (HCC), gastric carcinoma and bladder cancer. Of note, the effect of circRNAs in HCC has drawn increasing public attention. Previous studies revealed that the function of circRNAs mainly consists of sponges of miRNA and RNA-binding proteins, alternative splicing of pre-mRNAs, transcriptional and translational regulators, and potential to encode proteins. In addition, recent research data indicate that the expression level of circRNAs is closely correlated with metastasis, invasion, and occurrence of HCC in patients. These findings imply that circRNAs may be useful as biomarkers for diagnosis and prediction of prognosis of HCC. In this review, we have systemically summarized current viewpoints regarding the role of circRNAs expression in HCC to provide an important reference illustrating the underlying mechanism of HCC. International Scientific Literature, Inc. 2020-08-11 /pmc/articles/PMC7441742/ /pubmed/32779638 http://dx.doi.org/10.12659/MSM.923832 Text en © Med Sci Monit, 2020 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Review Articles
Zou, Ren-Chao
Li, Ling-Lin
Yuan, Hong-Ling
Current Status of Research on the Role of Circular RNAs in Hepatocellular Carcinoma and Clinical Implications
title Current Status of Research on the Role of Circular RNAs in Hepatocellular Carcinoma and Clinical Implications
title_full Current Status of Research on the Role of Circular RNAs in Hepatocellular Carcinoma and Clinical Implications
title_fullStr Current Status of Research on the Role of Circular RNAs in Hepatocellular Carcinoma and Clinical Implications
title_full_unstemmed Current Status of Research on the Role of Circular RNAs in Hepatocellular Carcinoma and Clinical Implications
title_short Current Status of Research on the Role of Circular RNAs in Hepatocellular Carcinoma and Clinical Implications
title_sort current status of research on the role of circular rnas in hepatocellular carcinoma and clinical implications
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7441742/
https://www.ncbi.nlm.nih.gov/pubmed/32779638
http://dx.doi.org/10.12659/MSM.923832
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