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The vaginal microbiome of sub-Saharan African women: revealing important gaps in the era of next-generation sequencing

Accurate characterization of the vaginal microbiome remains a fundamental goal of the Human Microbiome project (HMP). For over a decade, this goal has been made possible deploying high-throughput next generation sequencing technologies (NGS), which indeed has revolutionized medical research and enab...

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Autores principales: Odogwu, Nkechi Martina, Olayemi, Oladapo O., Omigbodun, Akinyinka O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7441984/
https://www.ncbi.nlm.nih.gov/pubmed/32879794
http://dx.doi.org/10.7717/peerj.9684
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author Odogwu, Nkechi Martina
Olayemi, Oladapo O.
Omigbodun, Akinyinka O.
author_facet Odogwu, Nkechi Martina
Olayemi, Oladapo O.
Omigbodun, Akinyinka O.
author_sort Odogwu, Nkechi Martina
collection PubMed
description Accurate characterization of the vaginal microbiome remains a fundamental goal of the Human Microbiome project (HMP). For over a decade, this goal has been made possible deploying high-throughput next generation sequencing technologies (NGS), which indeed has revolutionized medical research and enabled large-scale genomic studies. The 16S rRNA marker-gene survey is the most commonly explored approach for vaginal microbial community studies. With this approach, prior studies have elucidated substantial variations in the vaginal microbiome of women from different ethnicities. This review provides a comprehensive account of studies that have deployed this approach to describe the vaginal microbiota of African women in health and disease. On the basis of published data, the few studies reported from the African population are mainly in non-pregnant post pubertal women and calls for more detailed studies in pregnant and postnatal cohorts. We provide insight on the use of more sophisticated cutting-edge technologies in characterizing the vaginal microbiome. These technologies offer high-resolution detection of vaginal microbiome variations and community functional capabilities, which can shed light into several discrepancies observed in the vaginal microbiota of African women in an African population versus women of African descent in the diaspora.
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spelling pubmed-74419842020-09-01 The vaginal microbiome of sub-Saharan African women: revealing important gaps in the era of next-generation sequencing Odogwu, Nkechi Martina Olayemi, Oladapo O. Omigbodun, Akinyinka O. PeerJ Microbiology Accurate characterization of the vaginal microbiome remains a fundamental goal of the Human Microbiome project (HMP). For over a decade, this goal has been made possible deploying high-throughput next generation sequencing technologies (NGS), which indeed has revolutionized medical research and enabled large-scale genomic studies. The 16S rRNA marker-gene survey is the most commonly explored approach for vaginal microbial community studies. With this approach, prior studies have elucidated substantial variations in the vaginal microbiome of women from different ethnicities. This review provides a comprehensive account of studies that have deployed this approach to describe the vaginal microbiota of African women in health and disease. On the basis of published data, the few studies reported from the African population are mainly in non-pregnant post pubertal women and calls for more detailed studies in pregnant and postnatal cohorts. We provide insight on the use of more sophisticated cutting-edge technologies in characterizing the vaginal microbiome. These technologies offer high-resolution detection of vaginal microbiome variations and community functional capabilities, which can shed light into several discrepancies observed in the vaginal microbiota of African women in an African population versus women of African descent in the diaspora. PeerJ Inc. 2020-08-18 /pmc/articles/PMC7441984/ /pubmed/32879794 http://dx.doi.org/10.7717/peerj.9684 Text en ©2020 Odogwu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Microbiology
Odogwu, Nkechi Martina
Olayemi, Oladapo O.
Omigbodun, Akinyinka O.
The vaginal microbiome of sub-Saharan African women: revealing important gaps in the era of next-generation sequencing
title The vaginal microbiome of sub-Saharan African women: revealing important gaps in the era of next-generation sequencing
title_full The vaginal microbiome of sub-Saharan African women: revealing important gaps in the era of next-generation sequencing
title_fullStr The vaginal microbiome of sub-Saharan African women: revealing important gaps in the era of next-generation sequencing
title_full_unstemmed The vaginal microbiome of sub-Saharan African women: revealing important gaps in the era of next-generation sequencing
title_short The vaginal microbiome of sub-Saharan African women: revealing important gaps in the era of next-generation sequencing
title_sort vaginal microbiome of sub-saharan african women: revealing important gaps in the era of next-generation sequencing
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7441984/
https://www.ncbi.nlm.nih.gov/pubmed/32879794
http://dx.doi.org/10.7717/peerj.9684
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