Cargando…
The Correlation Between Clinical Features and Viral RNA Shedding in Outpatients With COVID-19
BACKGROUND: Patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can shed virus, thereby causing human-to-human transmission, and the viral RNA shedding is commonly used as a proxy measure for infectivity. METHODS: We retrospectively reviewed confirmed cases of COVID-1...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442275/ https://www.ncbi.nlm.nih.gov/pubmed/32851112 http://dx.doi.org/10.1093/ofid/ofaa331 |
_version_ | 1783573440705331200 |
---|---|
author | Liao, Tingting Yin, Zhengrong Xu, Juanjuan Lv, Zhilei Wang, Sufei Duan, Limin Fan, Jinshuo Jin, Yang |
author_facet | Liao, Tingting Yin, Zhengrong Xu, Juanjuan Lv, Zhilei Wang, Sufei Duan, Limin Fan, Jinshuo Jin, Yang |
author_sort | Liao, Tingting |
collection | PubMed |
description | BACKGROUND: Patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can shed virus, thereby causing human-to-human transmission, and the viral RNA shedding is commonly used as a proxy measure for infectivity. METHODS: We retrospectively reviewed confirmed cases of COVID-19 who attended the fever clinic of Wuhan Union Hospital from January 14 to February 24. In terms of the viral RNA shedding (median values) at first visit, patients were divided into a high–viral RNA shedding group and a low–viral RNA shedding group. Univariate and multivariate logistic regression analysis were performed to investigate the correlation between viral RNA shedding and clinical features. RESULTS: A total of 918 consecutive COVID-19 patients were enrolled, and severe patients made up 26.1%. After univariate and multivariate logistic regression, advanced age (odds ratio [OR], 1.02; 95% CI, 1.01–1.03; P = .001), having severe chronic diseases (OR, 1.44; 95% CI, 1.03–2.01; P = .04), and severe illness (OR, 1.60; 95% CI, 1.12–2.28; P = .01) were independent risk factors for high viral RNA shedding. Shorter time interval from symptom onset to viral detection was a protective factor for viral RNA shedding (OR, 0.97; 95% CI, 0.94–0.99; P = .01). Compared with mild patients, severe patients have higher virus shedding over a long period of time after symptom onset (P = .01). CONCLUSIONS: Outpatients who were old, had severe illness, and had severe underlying diseases had high viral RNA shedding. |
format | Online Article Text |
id | pubmed-7442275 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-74422752020-08-25 The Correlation Between Clinical Features and Viral RNA Shedding in Outpatients With COVID-19 Liao, Tingting Yin, Zhengrong Xu, Juanjuan Lv, Zhilei Wang, Sufei Duan, Limin Fan, Jinshuo Jin, Yang Open Forum Infect Dis Major Articles BACKGROUND: Patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can shed virus, thereby causing human-to-human transmission, and the viral RNA shedding is commonly used as a proxy measure for infectivity. METHODS: We retrospectively reviewed confirmed cases of COVID-19 who attended the fever clinic of Wuhan Union Hospital from January 14 to February 24. In terms of the viral RNA shedding (median values) at first visit, patients were divided into a high–viral RNA shedding group and a low–viral RNA shedding group. Univariate and multivariate logistic regression analysis were performed to investigate the correlation between viral RNA shedding and clinical features. RESULTS: A total of 918 consecutive COVID-19 patients were enrolled, and severe patients made up 26.1%. After univariate and multivariate logistic regression, advanced age (odds ratio [OR], 1.02; 95% CI, 1.01–1.03; P = .001), having severe chronic diseases (OR, 1.44; 95% CI, 1.03–2.01; P = .04), and severe illness (OR, 1.60; 95% CI, 1.12–2.28; P = .01) were independent risk factors for high viral RNA shedding. Shorter time interval from symptom onset to viral detection was a protective factor for viral RNA shedding (OR, 0.97; 95% CI, 0.94–0.99; P = .01). Compared with mild patients, severe patients have higher virus shedding over a long period of time after symptom onset (P = .01). CONCLUSIONS: Outpatients who were old, had severe illness, and had severe underlying diseases had high viral RNA shedding. Oxford University Press 2020-08-07 /pmc/articles/PMC7442275/ /pubmed/32851112 http://dx.doi.org/10.1093/ofid/ofaa331 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Major Articles Liao, Tingting Yin, Zhengrong Xu, Juanjuan Lv, Zhilei Wang, Sufei Duan, Limin Fan, Jinshuo Jin, Yang The Correlation Between Clinical Features and Viral RNA Shedding in Outpatients With COVID-19 |
title | The Correlation Between Clinical Features and Viral RNA Shedding in Outpatients With COVID-19 |
title_full | The Correlation Between Clinical Features and Viral RNA Shedding in Outpatients With COVID-19 |
title_fullStr | The Correlation Between Clinical Features and Viral RNA Shedding in Outpatients With COVID-19 |
title_full_unstemmed | The Correlation Between Clinical Features and Viral RNA Shedding in Outpatients With COVID-19 |
title_short | The Correlation Between Clinical Features and Viral RNA Shedding in Outpatients With COVID-19 |
title_sort | correlation between clinical features and viral rna shedding in outpatients with covid-19 |
topic | Major Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442275/ https://www.ncbi.nlm.nih.gov/pubmed/32851112 http://dx.doi.org/10.1093/ofid/ofaa331 |
work_keys_str_mv | AT liaotingting thecorrelationbetweenclinicalfeaturesandviralrnasheddinginoutpatientswithcovid19 AT yinzhengrong thecorrelationbetweenclinicalfeaturesandviralrnasheddinginoutpatientswithcovid19 AT xujuanjuan thecorrelationbetweenclinicalfeaturesandviralrnasheddinginoutpatientswithcovid19 AT lvzhilei thecorrelationbetweenclinicalfeaturesandviralrnasheddinginoutpatientswithcovid19 AT wangsufei thecorrelationbetweenclinicalfeaturesandviralrnasheddinginoutpatientswithcovid19 AT duanlimin thecorrelationbetweenclinicalfeaturesandviralrnasheddinginoutpatientswithcovid19 AT fanjinshuo thecorrelationbetweenclinicalfeaturesandviralrnasheddinginoutpatientswithcovid19 AT jinyang thecorrelationbetweenclinicalfeaturesandviralrnasheddinginoutpatientswithcovid19 AT liaotingting correlationbetweenclinicalfeaturesandviralrnasheddinginoutpatientswithcovid19 AT yinzhengrong correlationbetweenclinicalfeaturesandviralrnasheddinginoutpatientswithcovid19 AT xujuanjuan correlationbetweenclinicalfeaturesandviralrnasheddinginoutpatientswithcovid19 AT lvzhilei correlationbetweenclinicalfeaturesandviralrnasheddinginoutpatientswithcovid19 AT wangsufei correlationbetweenclinicalfeaturesandviralrnasheddinginoutpatientswithcovid19 AT duanlimin correlationbetweenclinicalfeaturesandviralrnasheddinginoutpatientswithcovid19 AT fanjinshuo correlationbetweenclinicalfeaturesandviralrnasheddinginoutpatientswithcovid19 AT jinyang correlationbetweenclinicalfeaturesandviralrnasheddinginoutpatientswithcovid19 |