Simultaneous targeting of DNA replication and homologous recombination in glioblastoma with a polyether ionophore

BACKGROUND: Despite significant endeavor having been applied to identify effective therapies to treat glioblastoma (GBM), survival outcomes remain intractable. The greatest nonsurgical benefit arises from radiotherapy, though tumors typically recur due to robust DNA repair. Patients could therefore...

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Detalles Bibliográficos
Autores principales: Lim, Yi Chieh, Ensbey, Kathleen S, Offenhäuser, Carolin, D’souza, Rochelle C J, Cullen, Jason K, Stringer, Brett W, Quek, Hazel, Bruce, Zara C, Kijas, Amanda, Cianfanelli, Valentina, Mahboubi, Bijan, Smith, Fiona, Jeffree, Rosalind L, Wiesmüeller, Lisa, Wiegmans, Adrian P, Bain, Amanda, Lombard, Fanny J, Roberts, Tara L, Khanna, Kum Kum, Lavin, Martin F, Kim, Baek, Hamerlik, Petra, Johns, Terrance G, Coster, Mark J, Boyd, Andrew W, Day, Bryan W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442340/
https://www.ncbi.nlm.nih.gov/pubmed/31504812
http://dx.doi.org/10.1093/neuonc/noz159

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