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The co-occurrence of multiple sclerosis and Evans syndrome: A case report

BACKGROUND: Evans syndrome is an uncommon autoimmune disorder manifested by fatigue, jaundice, pallor, purpura and petechiae. The main characteristics of this rare disease are simultaneous or sequential existence of positive anti-globulin test, immune thrombocytopenia (ITP) and autoimmune hemolytic...

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Autores principales: Salehizadeh, Saeideh, Naser Moghadasi, Abdorreza, Sahrain, Mohammad Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Babol University of Medical Sciences 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442462/
https://www.ncbi.nlm.nih.gov/pubmed/32874446
http://dx.doi.org/10.22088/cjim.11.3.343
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author Salehizadeh, Saeideh
Naser Moghadasi, Abdorreza
Sahrain, Mohammad Ali
author_facet Salehizadeh, Saeideh
Naser Moghadasi, Abdorreza
Sahrain, Mohammad Ali
author_sort Salehizadeh, Saeideh
collection PubMed
description BACKGROUND: Evans syndrome is an uncommon autoimmune disorder manifested by fatigue, jaundice, pallor, purpura and petechiae. The main characteristics of this rare disease are simultaneous or sequential existence of positive anti-globulin test, immune thrombocytopenia (ITP) and autoimmune hemolytic anemia (AIHA). Evans syndrome as an autoimmune disorder can be associated with other diseases. The concomitancy of Evans syndrome and multiple sclerosis (MS) has not been reported so far. In this case study, a -21-year old male with concomitant Evans syndrome and MS has been reported. CASE PRESENTATION: A 21-year-old male of Iranian origin and known case of Evans syndrome, was referred to our hospital for better evaluation. Evans syndrome was presented with acute jaundice, purpura, petechiae, and easy bruising when he was 9.He was under treatment of corticosteroid and cytotoxic agents, and presented with left lower extremity paresis for 5 months before admission to our hospital. According to neuroimaging and pathologic results, multiple sclerosis (MS) was diagnosed. Hence, we decided to treat the patient with rituximab. The patient has been stable without any further exacerbation or increase in disability progression after 2 years from diagnosis. CONCLUSION: Evans syndrome can be associated with other autoimmune disorders. For our case, we have reported this association with MS.
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spelling pubmed-74424622020-08-31 The co-occurrence of multiple sclerosis and Evans syndrome: A case report Salehizadeh, Saeideh Naser Moghadasi, Abdorreza Sahrain, Mohammad Ali Caspian J Intern Med Case Report BACKGROUND: Evans syndrome is an uncommon autoimmune disorder manifested by fatigue, jaundice, pallor, purpura and petechiae. The main characteristics of this rare disease are simultaneous or sequential existence of positive anti-globulin test, immune thrombocytopenia (ITP) and autoimmune hemolytic anemia (AIHA). Evans syndrome as an autoimmune disorder can be associated with other diseases. The concomitancy of Evans syndrome and multiple sclerosis (MS) has not been reported so far. In this case study, a -21-year old male with concomitant Evans syndrome and MS has been reported. CASE PRESENTATION: A 21-year-old male of Iranian origin and known case of Evans syndrome, was referred to our hospital for better evaluation. Evans syndrome was presented with acute jaundice, purpura, petechiae, and easy bruising when he was 9.He was under treatment of corticosteroid and cytotoxic agents, and presented with left lower extremity paresis for 5 months before admission to our hospital. According to neuroimaging and pathologic results, multiple sclerosis (MS) was diagnosed. Hence, we decided to treat the patient with rituximab. The patient has been stable without any further exacerbation or increase in disability progression after 2 years from diagnosis. CONCLUSION: Evans syndrome can be associated with other autoimmune disorders. For our case, we have reported this association with MS. Babol University of Medical Sciences 2020-05 /pmc/articles/PMC7442462/ /pubmed/32874446 http://dx.doi.org/10.22088/cjim.11.3.343 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Salehizadeh, Saeideh
Naser Moghadasi, Abdorreza
Sahrain, Mohammad Ali
The co-occurrence of multiple sclerosis and Evans syndrome: A case report
title The co-occurrence of multiple sclerosis and Evans syndrome: A case report
title_full The co-occurrence of multiple sclerosis and Evans syndrome: A case report
title_fullStr The co-occurrence of multiple sclerosis and Evans syndrome: A case report
title_full_unstemmed The co-occurrence of multiple sclerosis and Evans syndrome: A case report
title_short The co-occurrence of multiple sclerosis and Evans syndrome: A case report
title_sort co-occurrence of multiple sclerosis and evans syndrome: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442462/
https://www.ncbi.nlm.nih.gov/pubmed/32874446
http://dx.doi.org/10.22088/cjim.11.3.343
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