Anti-α(4)β(7) monoclonal antibody–conjugated nanoparticles block integrin α(4)β(7) on intravaginal T cells in rhesus macaques

Intravenous administration of anti-α(4)β(7) monoclonal antibody in macaques decreases simian immunodeficiency virus (SIV) vaginal infection and reduces gut SIV loads. Because of potential side effects of systemic administration, a prophylactic strategy based on mucosal administration of anti-α(4)β(7...

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Detalles Bibliográficos
Autores principales: Yang, Sidi, Arrode-Bruses, Geraldine, Frank, Ines, Grasperge, Brooke, Blanchard, James, Gettie, Agegnehu, Martinelli, Elena, Ho, Emmanuel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442472/
https://www.ncbi.nlm.nih.gov/pubmed/32937372
http://dx.doi.org/10.1126/sciadv.abb9853

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442472/
https://www.ncbi.nlm.nih.gov/pubmed/32937372
http://dx.doi.org/10.1126/sciadv.abb9853

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