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Diabetes, glycaemic control, and risk of COVID-19 hospitalisation: Population-based, prospective cohort study

OBJECTIVE: We aimed to examine the prospective association of diabetes and glycaemic control with COVID-19 hospitalisation in a large community-based cohort study. METHODS AND STUDY DESIGN: Participants (N = 337,802, aged 56.4 ± 8.1 yr; 55.1% women) underwent biomedical assessments at baseline as pa...

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Detalles Bibliográficos
Autores principales: Hamer, Mark, Gale, Catharine R., Batty, G. David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442562/
https://www.ncbi.nlm.nih.gov/pubmed/32835758
http://dx.doi.org/10.1016/j.metabol.2020.154344
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author Hamer, Mark
Gale, Catharine R.
Batty, G. David
author_facet Hamer, Mark
Gale, Catharine R.
Batty, G. David
author_sort Hamer, Mark
collection PubMed
description OBJECTIVE: We aimed to examine the prospective association of diabetes and glycaemic control with COVID-19 hospitalisation in a large community-based cohort study. METHODS AND STUDY DESIGN: Participants (N = 337,802, aged 56.4 ± 8.1 yr; 55.1% women) underwent biomedical assessments at baseline as part of the UK Biobank prospective cohort study. The outcome was cases of COVID-19 serious enough to warrant a hospital admission from 16-March-2020 to 26-April-2020. RESULTS: At follow up, 649 cases COVID-19 were recorded. In multivariable adjusted analyses, risk of COVID-19 was elevated in people with undiagnosed diabetes at baseline (A1C ≥ 6.5%) (risk ratio = 2.68; 95% confidence interval: 1.66, 4.33) and poorly controlled (A1C ≥ 8.6%) diagnosed diabetes (1.91;1.04, 3.52). There was a dose-dependent increase in risk of COVID-19 with increasing A1C, that persisted in multivariable adjusted models (per SD [0.9%]: 1.07; 1.03, 1.11; p[trend] < 0.001). CONCLUSION: In this large community-based sample, higher levels of A1C within the normal range were a risk factor for COVID-19. Glucose regulation may play a key role in immune responses to this infection. Undiagnosed cases of diabetes in the general community may present a particularly high risk.
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spelling pubmed-74425622020-08-24 Diabetes, glycaemic control, and risk of COVID-19 hospitalisation: Population-based, prospective cohort study Hamer, Mark Gale, Catharine R. Batty, G. David Metabolism COVID-19 in Metabolism OBJECTIVE: We aimed to examine the prospective association of diabetes and glycaemic control with COVID-19 hospitalisation in a large community-based cohort study. METHODS AND STUDY DESIGN: Participants (N = 337,802, aged 56.4 ± 8.1 yr; 55.1% women) underwent biomedical assessments at baseline as part of the UK Biobank prospective cohort study. The outcome was cases of COVID-19 serious enough to warrant a hospital admission from 16-March-2020 to 26-April-2020. RESULTS: At follow up, 649 cases COVID-19 were recorded. In multivariable adjusted analyses, risk of COVID-19 was elevated in people with undiagnosed diabetes at baseline (A1C ≥ 6.5%) (risk ratio = 2.68; 95% confidence interval: 1.66, 4.33) and poorly controlled (A1C ≥ 8.6%) diagnosed diabetes (1.91;1.04, 3.52). There was a dose-dependent increase in risk of COVID-19 with increasing A1C, that persisted in multivariable adjusted models (per SD [0.9%]: 1.07; 1.03, 1.11; p[trend] < 0.001). CONCLUSION: In this large community-based sample, higher levels of A1C within the normal range were a risk factor for COVID-19. Glucose regulation may play a key role in immune responses to this infection. Undiagnosed cases of diabetes in the general community may present a particularly high risk. Elsevier Inc. 2020-11 2020-08-22 /pmc/articles/PMC7442562/ /pubmed/32835758 http://dx.doi.org/10.1016/j.metabol.2020.154344 Text en © 2020 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle COVID-19 in Metabolism
Hamer, Mark
Gale, Catharine R.
Batty, G. David
Diabetes, glycaemic control, and risk of COVID-19 hospitalisation: Population-based, prospective cohort study
title Diabetes, glycaemic control, and risk of COVID-19 hospitalisation: Population-based, prospective cohort study
title_full Diabetes, glycaemic control, and risk of COVID-19 hospitalisation: Population-based, prospective cohort study
title_fullStr Diabetes, glycaemic control, and risk of COVID-19 hospitalisation: Population-based, prospective cohort study
title_full_unstemmed Diabetes, glycaemic control, and risk of COVID-19 hospitalisation: Population-based, prospective cohort study
title_short Diabetes, glycaemic control, and risk of COVID-19 hospitalisation: Population-based, prospective cohort study
title_sort diabetes, glycaemic control, and risk of covid-19 hospitalisation: population-based, prospective cohort study
topic COVID-19 in Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442562/
https://www.ncbi.nlm.nih.gov/pubmed/32835758
http://dx.doi.org/10.1016/j.metabol.2020.154344
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