Neuropilin-1 is a T cell memory checkpoint limiting long-term anti-tumor immunity

Robust CD8(+) T cell memory is essential for long-term protective immunity, but is often compromised in cancer where T cell exhaustion leads to loss of memory precursors. Immunotherapy via checkpoint blockade may not effectively reverse this defect, potentially underlying disease relapse. Here we re...

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Detalles Bibliográficos
Autores principales: Liu, Chang, Somasundaram, Ashwin, Manne, Sasikanth, Gocher, Angela M., Szymczak-Workman, Andrea L., Vignali, Kate M., Scott, Ellen N., Normolle, Daniel P., Wherry, E. John, Lipson, Evan J., Ferris, Robert L., Bruno, Tullia C., Workman, Creg J., Vignali, Dario A. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442600/
https://www.ncbi.nlm.nih.gov/pubmed/32661362
http://dx.doi.org/10.1038/s41590-020-0733-2

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