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Remote Allergen Exposure Elicits Eosinophil Infiltration into Allergen Non-Exposed Mucosal Organs and Primes for Allergic Inflammation
The natural history of allergic diseases suggests bidirectional and progressive relationships between allergic disorders of the skin, lung and gut indicative of mucosal organ cross-talk. However, impacts of local allergic inflammation on the cellular landscape of remote mucosal organs along the skin...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442625/ https://www.ncbi.nlm.nih.gov/pubmed/32518365 http://dx.doi.org/10.1038/s41385-020-0310-x |
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author | Olbrich, Courtney L. Bivas-Benita, Maytal Xenakis, Jason J. Maldonado, Samuel Cornwell, Evangeline Fink, Julia Yuan, Qitong Gill, Nathan Mansfield, Ryan Dockstader, Karen Spencer, Lisa A. |
author_facet | Olbrich, Courtney L. Bivas-Benita, Maytal Xenakis, Jason J. Maldonado, Samuel Cornwell, Evangeline Fink, Julia Yuan, Qitong Gill, Nathan Mansfield, Ryan Dockstader, Karen Spencer, Lisa A. |
author_sort | Olbrich, Courtney L. |
collection | PubMed |
description | The natural history of allergic diseases suggests bidirectional and progressive relationships between allergic disorders of the skin, lung and gut indicative of mucosal organ cross-talk. However, impacts of local allergic inflammation on the cellular landscape of remote mucosal organs along the skin:lung:gut axis are not yet known. Eosinophils are tissue-dwelling innate immune leukocytes associated with allergic diseases. Emerging data suggest heterogeneous phenotypes of tissue-dwelling eosinophils contribute to multifaceted roles that favor homeostasis or disease. This study investigated the impact of acute local allergen exposure on the frequency and phenotype of tissue eosinophils within remote mucosal organs. Our findings demonstrate allergen challenge to skin, lung or gut elicited not only local eosinophilic inflammation, but also increased the number and frequency of eosinophils within remote, allergen non-exposed lung and intestine. Remote allergen-elicited lung eosinophils exhibited an inflammatory phenotype and their presence associated with enhanced susceptibility to airway inflammation induced upon subsequent inhalation of a different allergen. These data demonstrate, for the first time, a direct effect of acute allergic inflammation on the phenotype and frequency of tissue eosinophils within antigen non-exposed remote mucosal tissues associated with remote organ priming for allergic inflammation. |
format | Online Article Text |
id | pubmed-7442625 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
record_format | MEDLINE/PubMed |
spelling | pubmed-74426252020-12-09 Remote Allergen Exposure Elicits Eosinophil Infiltration into Allergen Non-Exposed Mucosal Organs and Primes for Allergic Inflammation Olbrich, Courtney L. Bivas-Benita, Maytal Xenakis, Jason J. Maldonado, Samuel Cornwell, Evangeline Fink, Julia Yuan, Qitong Gill, Nathan Mansfield, Ryan Dockstader, Karen Spencer, Lisa A. Mucosal Immunol Article The natural history of allergic diseases suggests bidirectional and progressive relationships between allergic disorders of the skin, lung and gut indicative of mucosal organ cross-talk. However, impacts of local allergic inflammation on the cellular landscape of remote mucosal organs along the skin:lung:gut axis are not yet known. Eosinophils are tissue-dwelling innate immune leukocytes associated with allergic diseases. Emerging data suggest heterogeneous phenotypes of tissue-dwelling eosinophils contribute to multifaceted roles that favor homeostasis or disease. This study investigated the impact of acute local allergen exposure on the frequency and phenotype of tissue eosinophils within remote mucosal organs. Our findings demonstrate allergen challenge to skin, lung or gut elicited not only local eosinophilic inflammation, but also increased the number and frequency of eosinophils within remote, allergen non-exposed lung and intestine. Remote allergen-elicited lung eosinophils exhibited an inflammatory phenotype and their presence associated with enhanced susceptibility to airway inflammation induced upon subsequent inhalation of a different allergen. These data demonstrate, for the first time, a direct effect of acute allergic inflammation on the phenotype and frequency of tissue eosinophils within antigen non-exposed remote mucosal tissues associated with remote organ priming for allergic inflammation. 2020-06-09 2020-09 /pmc/articles/PMC7442625/ /pubmed/32518365 http://dx.doi.org/10.1038/s41385-020-0310-x Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Olbrich, Courtney L. Bivas-Benita, Maytal Xenakis, Jason J. Maldonado, Samuel Cornwell, Evangeline Fink, Julia Yuan, Qitong Gill, Nathan Mansfield, Ryan Dockstader, Karen Spencer, Lisa A. Remote Allergen Exposure Elicits Eosinophil Infiltration into Allergen Non-Exposed Mucosal Organs and Primes for Allergic Inflammation |
title | Remote Allergen Exposure Elicits Eosinophil Infiltration into Allergen Non-Exposed Mucosal Organs and Primes for Allergic Inflammation |
title_full | Remote Allergen Exposure Elicits Eosinophil Infiltration into Allergen Non-Exposed Mucosal Organs and Primes for Allergic Inflammation |
title_fullStr | Remote Allergen Exposure Elicits Eosinophil Infiltration into Allergen Non-Exposed Mucosal Organs and Primes for Allergic Inflammation |
title_full_unstemmed | Remote Allergen Exposure Elicits Eosinophil Infiltration into Allergen Non-Exposed Mucosal Organs and Primes for Allergic Inflammation |
title_short | Remote Allergen Exposure Elicits Eosinophil Infiltration into Allergen Non-Exposed Mucosal Organs and Primes for Allergic Inflammation |
title_sort | remote allergen exposure elicits eosinophil infiltration into allergen non-exposed mucosal organs and primes for allergic inflammation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442625/ https://www.ncbi.nlm.nih.gov/pubmed/32518365 http://dx.doi.org/10.1038/s41385-020-0310-x |
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