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Hyperspectral Imaging and the Retina: Worth the Wave?

PURPOSE: Hyperspectral imaging is gaining attention in the biomedical field because it generates additional spectral information to study physiological and clinical processes. Several technologies have been described; however an independent, systematic literature overview is lacking, especially in t...

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Autores principales: Lemmens, Sophie, Van Eijgen, Jan, Van Keer, Karel, Jacob, Julie, Moylett, Sinéad, De Groef, Lies, Vancraenendonck, Toon, De Boever, Patrick, Stalmans, Ingeborg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442879/
https://www.ncbi.nlm.nih.gov/pubmed/32879765
http://dx.doi.org/10.1167/tvst.9.9.9
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author Lemmens, Sophie
Van Eijgen, Jan
Van Keer, Karel
Jacob, Julie
Moylett, Sinéad
De Groef, Lies
Vancraenendonck, Toon
De Boever, Patrick
Stalmans, Ingeborg
author_facet Lemmens, Sophie
Van Eijgen, Jan
Van Keer, Karel
Jacob, Julie
Moylett, Sinéad
De Groef, Lies
Vancraenendonck, Toon
De Boever, Patrick
Stalmans, Ingeborg
author_sort Lemmens, Sophie
collection PubMed
description PURPOSE: Hyperspectral imaging is gaining attention in the biomedical field because it generates additional spectral information to study physiological and clinical processes. Several technologies have been described; however an independent, systematic literature overview is lacking, especially in the field of ophthalmology. This investigation is the first to systematically overview scientific literature specifically regarding retinal hyperspectral imaging. METHODS: A systematic literature review was conducted, in accordance with PRISMA Statement 2009 criteria, in four bibliographic databases: Medline, Embase, Cochrane Database of Systematic Reviews, and Web of Science. RESULTS: Fifty-six articles were found that meet the review criteria. A range of techniques was reported: Fourier analysis, liquid crystal tunable filters, tunable laser sources, dual-slit monochromators, dispersive prisms and gratings, computed tomography, fiber optics, and Fabry-Perrot cavity filter covered complementary metal oxide semiconductor. We present a narrative synthesis and summary tables of findings of the included articles, because methodologic heterogeneity and diverse research topics prevented a meta-analysis being conducted. CONCLUSIONS: Application in ophthalmology is still in its infancy. Most previous experiments have been performed in the field of retinal oximetry, providing valuable information in the diagnosis and monitoring of various ocular diseases. To date, none of these applications have graduated to clinical practice owing to the lack of sufficiently large validation studies. TRANSLATIONAL RELEVANCE: Given the promising results that smaller studies show for hyperspectral imaging (e.g., in Alzheimer's disease), advanced research in larger validation studies is warranted to determine its true clinical potential.
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spelling pubmed-74428792020-09-01 Hyperspectral Imaging and the Retina: Worth the Wave? Lemmens, Sophie Van Eijgen, Jan Van Keer, Karel Jacob, Julie Moylett, Sinéad De Groef, Lies Vancraenendonck, Toon De Boever, Patrick Stalmans, Ingeborg Transl Vis Sci Technol Review PURPOSE: Hyperspectral imaging is gaining attention in the biomedical field because it generates additional spectral information to study physiological and clinical processes. Several technologies have been described; however an independent, systematic literature overview is lacking, especially in the field of ophthalmology. This investigation is the first to systematically overview scientific literature specifically regarding retinal hyperspectral imaging. METHODS: A systematic literature review was conducted, in accordance with PRISMA Statement 2009 criteria, in four bibliographic databases: Medline, Embase, Cochrane Database of Systematic Reviews, and Web of Science. RESULTS: Fifty-six articles were found that meet the review criteria. A range of techniques was reported: Fourier analysis, liquid crystal tunable filters, tunable laser sources, dual-slit monochromators, dispersive prisms and gratings, computed tomography, fiber optics, and Fabry-Perrot cavity filter covered complementary metal oxide semiconductor. We present a narrative synthesis and summary tables of findings of the included articles, because methodologic heterogeneity and diverse research topics prevented a meta-analysis being conducted. CONCLUSIONS: Application in ophthalmology is still in its infancy. Most previous experiments have been performed in the field of retinal oximetry, providing valuable information in the diagnosis and monitoring of various ocular diseases. To date, none of these applications have graduated to clinical practice owing to the lack of sufficiently large validation studies. TRANSLATIONAL RELEVANCE: Given the promising results that smaller studies show for hyperspectral imaging (e.g., in Alzheimer's disease), advanced research in larger validation studies is warranted to determine its true clinical potential. The Association for Research in Vision and Ophthalmology 2020-08-05 /pmc/articles/PMC7442879/ /pubmed/32879765 http://dx.doi.org/10.1167/tvst.9.9.9 Text en Copyright 2020 The Authors http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License.
spellingShingle Review
Lemmens, Sophie
Van Eijgen, Jan
Van Keer, Karel
Jacob, Julie
Moylett, Sinéad
De Groef, Lies
Vancraenendonck, Toon
De Boever, Patrick
Stalmans, Ingeborg
Hyperspectral Imaging and the Retina: Worth the Wave?
title Hyperspectral Imaging and the Retina: Worth the Wave?
title_full Hyperspectral Imaging and the Retina: Worth the Wave?
title_fullStr Hyperspectral Imaging and the Retina: Worth the Wave?
title_full_unstemmed Hyperspectral Imaging and the Retina: Worth the Wave?
title_short Hyperspectral Imaging and the Retina: Worth the Wave?
title_sort hyperspectral imaging and the retina: worth the wave?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442879/
https://www.ncbi.nlm.nih.gov/pubmed/32879765
http://dx.doi.org/10.1167/tvst.9.9.9
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