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The Value of Voltage Histogram Analysis Derived Right Atrial Scar Burden in the Prediction of Left Atrial Scar Burden

INTRODUCTION: Growing evidence suggests that fibrotic changes can be observed in atrial fibrillation (AF) in both atria. Quantification of the scar burden during electroanatomical mapping might have important therapeutic and prognostic consequences. However, as the current invasive treatment of AF i...

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Autores principales: Herczeg, Szilvia, Galvin, Joseph, Keaney, John J., Keelan, Edward, Byrne, Roger, Howard, Claire, Geller, Laszlo, Szeplaki, Gabor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442993/
https://www.ncbi.nlm.nih.gov/pubmed/32855820
http://dx.doi.org/10.1155/2020/3981684
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author Herczeg, Szilvia
Galvin, Joseph
Keaney, John J.
Keelan, Edward
Byrne, Roger
Howard, Claire
Geller, Laszlo
Szeplaki, Gabor
author_facet Herczeg, Szilvia
Galvin, Joseph
Keaney, John J.
Keelan, Edward
Byrne, Roger
Howard, Claire
Geller, Laszlo
Szeplaki, Gabor
author_sort Herczeg, Szilvia
collection PubMed
description INTRODUCTION: Growing evidence suggests that fibrotic changes can be observed in atrial fibrillation (AF) in both atria. Quantification of the scar burden during electroanatomical mapping might have important therapeutic and prognostic consequences. However, as the current invasive treatment of AF is focused on the left atrium (LA), the role of the right atrium (RA) is less well understood. We aimed to characterize the clinical determinates of the RA low-voltage burden and its relation to the LA scaring. METHODS: We have included 36 patients who underwent catheter ablation for AF in a prospective observational study. In addition to LA mapping and ablation, high-density RA bipolar voltage maps (HD-EAM) were also reconstructed. The extent of the diseased RA tissue (≤0.5 mV) was quantified using the voltage histogram analysis tool (CARTO(®)3, Biosense Webster). RESULTS: The percentage of RA diseased tissue burden was significantly higher in patients with a CHA(2)DS(2)-VASc score ≥ 2 (p = 0.0305), higher indexed LA volume on the CTA scan and on the HD‐EAM (p = 0.0223 and p = 0.0064, respectively), or higher indexed RA volume on the HD‐EAM (p = 0.0026). High RA diseased tissue burden predicted the presence of high LA diseased tissue burden (OR = 7.1, CI (95%): 1.3–38.9, p = 0.0145), and there was a significant correlation of the same (r = 0.6461, p < 0.0001). CONCLUSIONS: Determining the extent of the right atrial low-voltage burden might give useful clinical information. According to our results, the diseased tissue burden correlates well between the two atria: the right atrium mirrors the left atrium.
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spelling pubmed-74429932020-08-26 The Value of Voltage Histogram Analysis Derived Right Atrial Scar Burden in the Prediction of Left Atrial Scar Burden Herczeg, Szilvia Galvin, Joseph Keaney, John J. Keelan, Edward Byrne, Roger Howard, Claire Geller, Laszlo Szeplaki, Gabor Cardiol Res Pract Research Article INTRODUCTION: Growing evidence suggests that fibrotic changes can be observed in atrial fibrillation (AF) in both atria. Quantification of the scar burden during electroanatomical mapping might have important therapeutic and prognostic consequences. However, as the current invasive treatment of AF is focused on the left atrium (LA), the role of the right atrium (RA) is less well understood. We aimed to characterize the clinical determinates of the RA low-voltage burden and its relation to the LA scaring. METHODS: We have included 36 patients who underwent catheter ablation for AF in a prospective observational study. In addition to LA mapping and ablation, high-density RA bipolar voltage maps (HD-EAM) were also reconstructed. The extent of the diseased RA tissue (≤0.5 mV) was quantified using the voltage histogram analysis tool (CARTO(®)3, Biosense Webster). RESULTS: The percentage of RA diseased tissue burden was significantly higher in patients with a CHA(2)DS(2)-VASc score ≥ 2 (p = 0.0305), higher indexed LA volume on the CTA scan and on the HD‐EAM (p = 0.0223 and p = 0.0064, respectively), or higher indexed RA volume on the HD‐EAM (p = 0.0026). High RA diseased tissue burden predicted the presence of high LA diseased tissue burden (OR = 7.1, CI (95%): 1.3–38.9, p = 0.0145), and there was a significant correlation of the same (r = 0.6461, p < 0.0001). CONCLUSIONS: Determining the extent of the right atrial low-voltage burden might give useful clinical information. According to our results, the diseased tissue burden correlates well between the two atria: the right atrium mirrors the left atrium. Hindawi 2020-08-13 /pmc/articles/PMC7442993/ /pubmed/32855820 http://dx.doi.org/10.1155/2020/3981684 Text en Copyright © 2020 Szilvia Herczeg et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Herczeg, Szilvia
Galvin, Joseph
Keaney, John J.
Keelan, Edward
Byrne, Roger
Howard, Claire
Geller, Laszlo
Szeplaki, Gabor
The Value of Voltage Histogram Analysis Derived Right Atrial Scar Burden in the Prediction of Left Atrial Scar Burden
title The Value of Voltage Histogram Analysis Derived Right Atrial Scar Burden in the Prediction of Left Atrial Scar Burden
title_full The Value of Voltage Histogram Analysis Derived Right Atrial Scar Burden in the Prediction of Left Atrial Scar Burden
title_fullStr The Value of Voltage Histogram Analysis Derived Right Atrial Scar Burden in the Prediction of Left Atrial Scar Burden
title_full_unstemmed The Value of Voltage Histogram Analysis Derived Right Atrial Scar Burden in the Prediction of Left Atrial Scar Burden
title_short The Value of Voltage Histogram Analysis Derived Right Atrial Scar Burden in the Prediction of Left Atrial Scar Burden
title_sort value of voltage histogram analysis derived right atrial scar burden in the prediction of left atrial scar burden
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442993/
https://www.ncbi.nlm.nih.gov/pubmed/32855820
http://dx.doi.org/10.1155/2020/3981684
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