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The Emerging Role of PPAR Beta/Delta in Tumor Angiogenesis
PPARs are ligand-activated transcriptional factors that belong to the nuclear receptor superfamily. Among them, PPAR alpha and PPAR gamma are prone to exert an antiangiogenic effect, whereas PPAR beta/delta has an opposite effect in physiological and pathological conditions. Angiogenesis has been kn...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443046/ https://www.ncbi.nlm.nih.gov/pubmed/32855630 http://dx.doi.org/10.1155/2020/3608315 |
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author | Du, Siyue Wagner, Nicole Wagner, Kay-Dietrich |
author_facet | Du, Siyue Wagner, Nicole Wagner, Kay-Dietrich |
author_sort | Du, Siyue |
collection | PubMed |
description | PPARs are ligand-activated transcriptional factors that belong to the nuclear receptor superfamily. Among them, PPAR alpha and PPAR gamma are prone to exert an antiangiogenic effect, whereas PPAR beta/delta has an opposite effect in physiological and pathological conditions. Angiogenesis has been known as a hallmark of cancer, and our recent works also demonstrate that vascular-specific PPAR beta/delta overexpression promotes tumor angiogenesis and progression in vivo. In this review, we will mainly focus on the role of PPAR beta/delta in tumor angiogenesis linked to the tumor microenvironment to further facilitate tumor progression and metastasis. Moreover, the crosstalk between PPAR beta/delta and its downstream key signal molecules involved in tumor angiogenesis will also be discussed, and the network of interplay between them will further be established in the review. |
format | Online Article Text |
id | pubmed-7443046 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-74430462020-08-26 The Emerging Role of PPAR Beta/Delta in Tumor Angiogenesis Du, Siyue Wagner, Nicole Wagner, Kay-Dietrich PPAR Res Review Article PPARs are ligand-activated transcriptional factors that belong to the nuclear receptor superfamily. Among them, PPAR alpha and PPAR gamma are prone to exert an antiangiogenic effect, whereas PPAR beta/delta has an opposite effect in physiological and pathological conditions. Angiogenesis has been known as a hallmark of cancer, and our recent works also demonstrate that vascular-specific PPAR beta/delta overexpression promotes tumor angiogenesis and progression in vivo. In this review, we will mainly focus on the role of PPAR beta/delta in tumor angiogenesis linked to the tumor microenvironment to further facilitate tumor progression and metastasis. Moreover, the crosstalk between PPAR beta/delta and its downstream key signal molecules involved in tumor angiogenesis will also be discussed, and the network of interplay between them will further be established in the review. Hindawi 2020-08-13 /pmc/articles/PMC7443046/ /pubmed/32855630 http://dx.doi.org/10.1155/2020/3608315 Text en Copyright © 2020 Siyue Du et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Du, Siyue Wagner, Nicole Wagner, Kay-Dietrich The Emerging Role of PPAR Beta/Delta in Tumor Angiogenesis |
title | The Emerging Role of PPAR Beta/Delta in Tumor Angiogenesis |
title_full | The Emerging Role of PPAR Beta/Delta in Tumor Angiogenesis |
title_fullStr | The Emerging Role of PPAR Beta/Delta in Tumor Angiogenesis |
title_full_unstemmed | The Emerging Role of PPAR Beta/Delta in Tumor Angiogenesis |
title_short | The Emerging Role of PPAR Beta/Delta in Tumor Angiogenesis |
title_sort | emerging role of ppar beta/delta in tumor angiogenesis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443046/ https://www.ncbi.nlm.nih.gov/pubmed/32855630 http://dx.doi.org/10.1155/2020/3608315 |
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